catalog number :
MBS7233075
products type :
ELISA Kit
products full name :
Chicken cocaine- and amphetamine-regulated transcript (non-HGNC gene) (CART) ELISA Kit
products short name :
cocaine- and amphetamine-regulated transcript (non-HGNC gene) (CART)
other names :
cocaine- and amphetamine-regulated transcript protein preproprotein; Cocaine- and amphetamine-regulated transcript protein; cocaine- and amphetamine-regulated transcript protein; cocaine and amphetamine regulated transcript; CART prepropeptide
products gene name :
CART
other gene names :
CARTPT; CARTPT; CART; CART
uniprot entry name :
CART_HUMAN
storage stability :
Store all reagents at 2-8 degree C.
ncbi acc num :
NP_004282.1
ncbi gb acc num :
NM_004291.3
ncbi mol weight :
12,829 Da
ncbi summary :
This gene encodes a secreted protein which is processed by prohormone/proprotein convertases to produce smaller, biologically active peptides. Expression of the transcript for this gene is regulated by certain drugs such as cocaine, and the encoded protein is thought to be involved in the regulation of appetite and stress. Mutations in this gene are associated with susceptibility to obesity.[provided by RefSeq, Nov 2009]
uniprot summary :
CARTPT: Satiety factor closely associated with the actions of leptin and neuropeptide y; this anorectic peptide inhibits both normal and starvation-induced feeding and completely blocks the feeding response induced by neuropeptide Y and regulated by leptin in the hypothalamus. It promotes neuronal development and survival in vitro. Belongs to the CART family. Protein type: Secreted; Hormone; Secreted, signal peptide; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 5q13.2. Cellular Component: extracellular space; secretory granule. Molecular Function: protein binding. Biological Process: negative regulation of osteoclast differentiation; activation of MAPKK activity; adult feeding behavior; cellular response to starvation; signal transduction; negative regulation of appetite; synaptic transmission; G-protein coupled receptor protein signaling pathway; cell-cell signaling; neuropeptide signaling pathway; positive regulation of epinephrine secretion; cell glucose homeostasis; circadian regulation of gene expression; negative regulation of bone resorption; regulation of insulin secretion; positive regulation of blood pressure; positive regulation of transmission of nerve impulse. Disease: Obesity