ELISA/assay

Canine 1-acyl-sn-glycerol-3-phosphate acyltransferase beta (AGPAT2) ELISA Kit

MBS7232205

48-Strip-Wells

470 USD

ELISA Kit

Canine 1-acyl-sn-glycerol-3-phosphate acyltransferase beta (AGPAT2) ELISA Kit

1-acyl-sn-glycerol-3-phosphate acyltransferase beta (AGPAT2)

1-acyl-sn-glycerol-3-phosphate acyltransferase beta isoform b; 1-acyl-sn-glycerol-3-phosphate acyltransferase beta; 1-acyl-sn-glycerol-3-phosphate acyltransferase beta; 1-AGPAT 2; 1-AGP acyltransferase 2; lysophosphatidic acid acyltransferase beta; lysophosphatidic acid acyltransferase-beta; 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta); 1-acylglycerol-3-phosphate O-acyltransferase 2; 1-acylglycerol-3-phosphate O-acyltransferase 2; 1-AGP acyltransferase 2; 1-AGPAT 2; Lysophosphatidic acid acyltransferase beta; LPAAT-beta

AGPAT2

AGPAT2; AGPAT2; BSCL; BSCL1; LPAAB; 1-AGPAT2; LPAAT-beta; 1-AGP acyltransferase 2; 1-AGPAT 2; LPAAT-beta

PLCB_HUMAN

Canine

Store all reagents at 2-8 degree C.

69122971

NP_001012745.1

NM_001012727.1

27,279 Da

Adipogenesis Pathway (198832); CDP-diacylglycerol Biosynthesis I Pathway (142255); CDP-diacylglycerol Biosynthesis I Pathway (138606); Fat Digestion And Absorption Pathway (194385); Fat Digestion And Absorption Pathway (194324); Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway (160977); Glycerolipid Metabolism Pathway (82986); Glycerolipid Metabolism Pathway (361); Glycerophospholipid Biosynthesis Pathway (645313); Glycerophospholipid Metabolism Pathway (82989)

This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. The protein is located within the endoplasmic reticulum membrane and converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. Mutations in this gene have been associated with congenital generalized lipodystrophy (CGL), or Berardinelli-Seip syndrome, a disease characterized by a near absence of adipose tissue and severe insulin resistance. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

AGPAT2: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Defects in AGPAT2 are the cause of congenital generalized lipodystrophy type 1 (CGL1); also known as Berardinelli-Seip congenital lipodystrophy type 1 (BSCL1) or Berardinelli-Seip syndrome. CGL1 is an autosomal recessive disorder characterized by marked paucity of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and early onset of diabetes. Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Lipid Metabolism - ether lipid; EC 2.3.1.51; Membrane protein, integral; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - glycerolipid; Transferase; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 9q34.3. Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; integral to membrane. Molecular Function: 1-acylglycerol-3-phosphate O-acyltransferase activity. Biological Process: positive regulation of cytokine production; epidermis development; phospholipid metabolic process; glycerophospholipid biosynthetic process; phosphatidic acid biosynthetic process; triacylglycerol biosynthetic process; cellular lipid metabolic process; positive regulation of cytokine and chemokine mediated signaling pathway; CDP-diacylglycerol biosynthetic process. Disease: Lipodystrophy, Congenital Generalized, Type 1

48-Strip-Wells

470 USD

96-Strip-Wells

675