Rat Fas/APO-1 ELISA Kit | MyBioSource MBS722722 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Rat Fas/APO-1 ELISA Kit

catalog :

MBS722722

quantity :

48-Strip-Wells-(Comp

price :

470 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS722722

products type :

ELISA Kit

products full name :

Rat Fas/APO-1 ELISA Kit

products short name :

Fas/APO-1

other names :

Fas/Apo-1/CD95; Tumor necrosis factor receptor superfamily member 6; tumor necrosis factor receptor superfamily member 6; Fas AMA; FAS 827dupA; CD95 antigen; FASLG receptor; apoptosis antigen 1; Delta Fas/APO-1/CD95; APO-1 cell surface antigen; apoptosis-mediating surface antigen FAS; tumor necrosis factor receptor superfamily, member 6; Fas (TNF receptor superfamily, member 6); Apo-1 antigen; Apoptosis-mediating surface antigen FAS; FASLG receptor

products gene name :

Fas / APO-1

other gene names :

FAS; FAS; APT1; CD95; FAS1; APO-1; FASTM; ALPS1A; TNFRSF6; APT1; FAS1; TNFRSF6

uniprot entry name :

TNR6_HUMAN

reactivity :

Rat

storage stability :

Store all reagents at 2-8 degree C

other info1 :

Assay Type: Competitive or Sandwich

other info2 :

Highest Standards: 5000 pg/mL. Concentration of Standards: Concentration of Standards: 0,250,500,1000,2500,5000 pg/mL

products categories :

Cell Biology

ncbi gi num :

887458

ncbi acc num :

CAA61473.1

uniprot acc num :

P25445

ncbi mol weight :

37,732 Da

ncbi pathways :

Activation Of Pro-Caspase 8 Pathway (105655); Adipogenesis Pathway (198832); African Trypanosomiasis Pathway (194384); African Trypanosomiasis Pathway (194323); Allograft Rejection Pathway (83123); Allograft Rejection Pathway (535); Alzheimer's Disease Pathway (83097); Alzheimer's Disease Pathway (509); Apoptosis Pathway (198797); Apoptosis Pathway (83060)

ncbi summary :

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform. [provided by RefSeq, Mar 2011]

uniprot summary :

Function: Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). Ref.4 Ref.24. Subunit structure: Binds DAXX. Interacts with HIPK3. Part of a complex containing HIPK3 and FADD . By similarity. Binds RIPK1 and FAIM2. Interacts with BRE and FEM1B. Interacts with FADD. Ref.14 Ref.15 Ref.16 Ref.18 Ref.21 Ref.24. Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein Ref.24. Isoform 2: Secreted Ref.24. Isoform 3: Secreted Ref.24. Isoform 4: Secreted Ref.24. Isoform 5: Secreted Ref.24. Isoform 6: Secreted Ref.24. Tissue specificity: Isoform 1 and isoform 6 are expressed at equal levels in resting peripheral blood mononuclear cells. After activation there is an increase in isoform 1 and decrease in the levels of isoform 6. Ref.3. Domain: Contains a death domain involved in the binding of FADD, and maybe to other cytosolic adapter proteins. Post-translational modification: N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. Ref.20 Ref.22. Involvement in disease: Defects in FAS are the cause of autoimmune lymphoproliferative syndrome type 1A (ALPS1A) [. MIM:601859]; also known as Canale-Smith syndrome (CSS). ALPS is a childhood syndrome involving hemolytic anemia and thrombocytopenia with massive lymphadenopathy and splenomegaly. Ref.6 Ref.25 Ref.26 Ref.27 Ref.28 Ref.29 Ref.31 Ref.32 Ref.33 Ref.34 Ref.35 Ref.37 Ref.38. Sequence similarities: Contains 1 death domain.Contains 3 TNFR-Cys repeats.

size1 :

48-Strip-Wells-(Competitive)

price1 :

470 USD

size2 :

48-Strip-Wells-(Sandwich)

price2 :

470

size3 :

96-Strip-Wells-(Competitive)

price3 :

675

size4 :

96-Strip-Wells-(Sandwich)

price4 :

675

more info or order :

MyBioSource product webpage