ELISA/assay

Mouse Podocalyxin ELISA Kit

MBS722547

48-Strip-Wells

470 USD

ELISA Kit

Mouse Podocalyxin ELISA Kit

Podocalyxin

podocalyxin isoform 1; Podocalyxin; podocalyxin; GCTM-2 antigen; podocalyxin-like protein 1; podocalyxin-like; GCTM-2 antigen; Gp200; Podocalyxin-like protein 1; PC; PCLP-1

PCX

PODXL; PODXL; PC; PCLP; Gp200; PCLP-1; PCLP; PCLP1; PC; PCLP-1

PODXL_HUMAN

Mouse

Store all reagents at 2-8 degree C.

Assay Type: Competitive

Highest Standards: 10ng/mL. Concentration of Standards: Concentration of Standards: 0,0.5,1.0,2.5,5.0,10ng/mL

Cell Biology

66277202

NP_001018121.1

NM_001018111.2

55,386 Da

This gene encodes a member of the sialomucin protein family. The encoded protein was originally identified as an important component of glomerular podocytes. Podocytes are highly differentiated epithelial cells with interdigitating foot processes covering the outer aspect of the glomerular basement membrane. Other biological activities of the encoded protein include: binding in a membrane protein complex with Na+/H+ exchanger regulatory factor to intracellular cytoskeletal elements, playing a role in hematopoetic cell differentiation, and being expressed in vascular endothelium cells and binding to L-selectin. [provided by RefSeq, Jul 2008]

PODXL: Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell- cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up inital epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR- dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells. Belongs to the podocalyxin family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Cell adhesion; Motility/polarity/chemotaxis; Membrane protein, integral. Chromosomal Location of Human Ortholog: 7q32-q33. Cellular Component: ruffle; extracellular space; lamellipodium; integral to plasma membrane; microvillus membrane; apical plasma membrane; cytoplasm; plasma membrane; lipid raft; filopodium. Molecular Function: protein binding. Biological Process: cell migration; negative regulation of cell-cell adhesion; negative regulation of cell adhesion; cell adhesion; leukocyte migration; positive regulation of cell-cell adhesion mediated by integrin; positive regulation of cell migration; regulation of microvillus biogenesis

48-Strip-Wells

470 USD

96-Strip-Wells

675