catalog number :
MBS722513
products type :
ELISA Kit
products full name :
Guinea pig Myeloperoxidase ELISA Kit
products short name :
Myeloperoxidase
other names :
myeloperoxidase; Myeloperoxidase; myeloperoxidase; myeloperoxidase
other gene names :
MPO; MPO; MPO
uniprot entry name :
PERM_HUMAN
storage stability :
Store all reagents at 2-8 degree C.
other info1 :
Assay Type: Competitive
other info2 :
Highest Standards: 100ng/mL. Concentration of Standards: Concentration of Standards: 0,5.0,10,25,50,100ng/mL
products categories :
Immunology
ncbi acc num :
AAA59863.1
ncbi mol weight :
87,248 Da
ncbi pathways :
C-MYB Transcription Factor Network Pathway (138073); Folate Metabolism Pathway (198833); IL23-mediated Signaling Events Pathway (138000); Phagosome Pathway (153910); Phagosome Pathway (153859); Selenium Pathway (198825); Transcriptional Misregulation In Cancer Pathway (523016); Transcriptional Misregulation In Cancer Pathway (522987); Vitamin B12 Metabolism Pathway (920974); Amb2 Integrin Signaling Pathway (137945)
ncbi summary :
Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of netrophils. [provided by RefSeq, Jul 2008]
uniprot summary :
MPO: Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. Homodimer; disulfide-linked. Each monomer consists of a light and a heavy chain. Belongs to the peroxidase family. XPO subfamily. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Oxidoreductase; EC 1.11.2.2. Chromosomal Location of Human Ortholog: 17q23.1. Cellular Component: extracellular space; azurophil granule; mitochondrion; lysosome; nucleus; secretory granule. Molecular Function: heparin binding; peroxidase activity; metal ion binding; heme binding; chromatin binding. Biological Process: respiratory burst during defense response; response to food; removal of superoxide radicals; hydrogen peroxide catabolic process; response to mechanical stimulus; response to lipopolysaccharide; response to yeast; defense response; response to oxidative stress; defense response to fungus; aging; negative regulation of apoptosis. Disease: Myeloperoxidase Deficiency; Alzheimer Disease