product summary
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company name :
MyBioSource
product type :
ELISA/assay
product name :
Human Heat Shock Factor 1 ELISA Kit
catalog :
MBS722401
quantity :
48-Strip-Wells-(Comp
price :
470 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS722401
products type :
ELISA Kit
products full name :
Human Heat Shock Factor 1 ELISA Kit
products short name :
Heat Shock Factor 1
other names :
heat shock factor protein 1; Heat shock factor protein 1; heat shock factor protein 1; HSF 1; HSTF 1; heat shock transcription factor 1; Heat shock transcription factor 1; HSTF 1
products gene name :
HSF1
other gene names :
HSF1; HSF1; HSTF1; HSTF1; HSF 1; HSTF 1
uniprot entry name :
HSF1_HUMAN
reactivity :
Human
storage stability :
Store all reagents at 2-8 degree C.
other info1 :
Assay Type: Competitive or Sandwich
other info2 :
Highest Standards: 10ng/mL. Concentration of Standards: Concentration of Standards: 0,0.5,1.0,2.5,5.0,10ng/mL
products categories :
Signal Transduction
ncbi gi num :
5031767
ncbi acc num :
NP_005517.1
ncbi gb acc num :
NM_005526.2
ncbi mol weight :
52,881 Da
ncbi pathways :
Attenuation Phase Pathway (980473); Cellular Response To Heat Stress Pathway (980470); Cellular Responses To Stress Pathway (645258); HSF1 Activation Pathway (980471); HSF1-dependent Transactivation Pathway (980472); Legionellosis Pathway (469200); Legionellosis Pathway (469186); Regulation Of HSF1-mediated Heat Shock Response Pathway (980474)
ncbi summary :
The product of this gene is a heat-shock transcription factor. Transcription of heat-shock genes is rapidly induced after temperature stress. Hsp90, by itself and/or associated with multichaperone complexes, is a major repressor of this gene. [provided by RefSeq, Jul 2008]
uniprot summary :
HSF1: a transcription factor that specifically binds heat shock promoter elements (HSE) and activates transcription. Induced in response to heat, heavy metals, and oxidative stress. In higher eukaryotes, HSF is unable to bind to HSEs unless the cells are stressed. Becomes phosphorylated in response to stress, forming homotrimers that bind DNA and activate transcription. Phosphorylation by PLK1 enhances nuclear translocation, and phosphorylation by CaMKII enhances transactivation. Phosphorylation by GSK3 and ERK1 induces binding by 14-3-3 and sequestration in the cytoplasm. In addition, during attenuation from the heat shock response, HSF1 is repressed by direct binding of Hsp70, HSP40, and HSF binding protein 1 (HSBP1). Four alternatively spliced isoforms have been described. Protein type: Transcription factor; DNA-binding. Chromosomal Location of Human Ortholog: 8q24.3. Cellular Component: nucleoplasm; protein complex; pronucleus; cytoplasm; cytosol. Molecular Function: protein binding; chromatin binding; transcription factor activity. Biological Process: embryonic placenta development; embryonic process involved in female pregnancy; female meiosis; defense response; response to lipopolysaccharide; positive regulation of multicellular organism growth; negative regulation of transcription from RNA polymerase II promoter; negative regulation of tumor necrosis factor production; protein amino acid phosphorylation; negative regulation of cell proliferation; mRNA transcription; positive regulation of transcription from RNA polymerase II promoter; spermatogenesis
size1 :
48-Strip-Wells-(Competitive)
price1 :
470 USD
size2 :
48-Strip-Wells-(Sandwich)
price2 :
470
size3 :
96-Strip-Wells-(Competitive)
price3 :
675
size4 :
96-Strip-Wells-(Sandwich)
price4 :
675
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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