ELISA/assay

Human Platelet Factor 4 ELISA Kit

MBS722309

48-Strip-Wells-(Comp

470 USD

ELISA Kit

Human Platelet Factor 4 ELISA Kit

Platelet Factor 4

platelet factor 4; Platelet factor 4; platelet factor 4; iroplact; oncostatin-A; C-X-C motif chemokine 4; chemokine (C-X-C motif) ligand 4; platelet factor 4; C-X-C motif chemokine 4; Iroplact; Oncostatin-ACleaved into the following chain:Platelet factor 4, short form

PF4

PF4; PF4; PF-4; CXCL4; SCYB4; CXCL4; SCYB4; PF-4

PLF4_HUMAN

Human

Store all reagents at 2-8 degree C.

Assay Type: Competitive or Sandwich

Highest Standards: 10ng/mL. Concentration of Standards: Concentration of Standards: 0,0.5,1.0,2.5,5.0,10ng/mL

Cardiovascular

4505733

NP_002610.1

NM_002619.3

10,845 Da

CXCR3-mediated Signaling Events Pathway (138011); Cell Surface Interactions At The Vascular Wall Pathway (106062); Chemokine Receptors Bind Chemokines Pathway (106359); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Common Pathway (106060); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Formation Of Fibrin Clot (Clotting Cascade) Pathway (106057)

This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function. [provided by RefSeq, Mar 2012]

PF4: Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form. Belongs to the intercrine alpha (chemokine CxC) family. Protein type: Apoptosis; Secreted, signal peptide; Chemokine; Secreted; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 4q12-q21. Cellular Component: extracellular space; extracellular region. Molecular Function: heparin binding; CXCR3 chemokine receptor binding; chemokine activity. Biological Process: negative regulation of cytolysis; platelet activation; cytokine and chemokine mediated signaling pathway; leukocyte chemotaxis; positive regulation of leukocyte chemotaxis; response to lipopolysaccharide; positive regulation of cAMP metabolic process; positive regulation of tumor necrosis factor production; negative regulation of megakaryocyte differentiation; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; platelet degranulation; negative regulation of MHC class II biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; immune response; positive regulation of macrophage differentiation; blood coagulation; inflammatory response

48-Strip-Wells-(Competitive)

470 USD

48-Strip-Wells-(Sandwich)

470

96-Strip-Wells-(Competitive)

675

96-Strip-Wells-(Sandwich)

675