ELISA/assay

Guinea pig Ferritin ELISA Kit

MBS722211

48-Strip-Wells

470 USD

ELISA Kit

Guinea pig Ferritin ELISA Kit

Ferritin

ferritin; Ferritin heavy chain; ferritin heavy chain; apoferritin; ferritin H subunit; placenta immunoregulatory factor; proliferation-inducing protein 15; cell proliferation-inducing gene 15 protein; ferritin, heavy polypeptide 1; Cell proliferation-inducing gene 15 proteinCleaved into the following chain:Ferritin heavy chain, N-terminally processed

FE

FTH1; FTH1; FHC; FTH; HFE5; PLIF; FTHL6; PIG15; FTH; FTHL6; OK/SW-cl.84; PIG15; Ferritin H subunit

FRIH_HUMAN

Guinea Pig

Store all reagents at 2-8 degree C.

Assay Type: Competitive

Highest Standards: 100ng/mL. Concentration of Standards: Concentration of Standards: 0,5.0,10,25,50,100ng/mL

Neurobiology

306744

AAA35832.1

21,226 Da

Binding And Uptake Of Ligands By Scavenger Receptors Pathway (771599); Clathrin Derived Vesicle Budding Pathway (119545); Golgi Associated Vesicle Biogenesis Pathway (119546); Iron Metabolism In Placenta Pathway (672461); Iron Uptake And Transport Pathway (187191); Membrane Trafficking Pathway (106160); Mineral Absorption Pathway (212237); Mineral Absorption Pathway (212220); Scavenging By Class A Receptors Pathway (833814); Transmembrane Transport Of Small Molecules Pathway (106572)

This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Ferritin-H: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited. Belongs to the ferritin family. Protein type: Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Oxidoreductase; EC 1.16.3.1. Chromosomal Location of Human Ortholog: 11q13. Cellular Component: ferritin complex; mitochondrion; nucleus; cytosol. Molecular Function: ferroxidase activity; protein binding; ferric iron binding; iron ion binding. Biological Process: receptor-mediated endocytosis; negative regulation of cell proliferation; negative regulation of fibroblast proliferation; cellular iron ion homeostasis; immune response; post-Golgi vesicle-mediated transport; transmembrane transport; iron ion transport; intracellular sequestering of iron ion. Disease: Hemochromatosis, Type 5

48-Strip-Wells

470 USD

96-Strip-Wells

675