ELISA/assay

Mouse Kallikrein 6 ELISA Kit

MBS721782

48-Strip-Wells

470 USD

ELISA Kit

Mouse Kallikrein 6 ELISA Kit

Kallikrein 6

kallikrein-6 isoform B; Kallikrein-6; kallikrein-6; zyme; neurosin; protease M; serine protease 9; serine protease 18; kallikrein-related peptidase 6; Neurosin; Protease M; SP59; Serine protease 18; Serine protease 9; Zyme

KLK6

KLK6; KLK6; hK6; Bssp; Klk7; SP59; PRSS9; PRSS18; PRSS18; PRSS9

KLK6_HUMAN

Mouse

Store all reagents at 2-8 degree C.

Signal Transduction

61744426

NP_001012983.1

NM_001012965.1

4,333 Da

Alpha-synuclein Signaling Pathway (137913)

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated by steroid hormones. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's disease. Multiple alternatively spliced transcript variants that encode different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

KLK6: Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis. Belongs to the peptidase S1 family. Kallikrein subfamily. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Protease; Secreted, signal peptide; EC 3.4.21.-; Nucleolus. Chromosomal Location of Human Ortholog: 19q13.3. Cellular Component: microtubule cytoskeleton; nucleoplasm; extracellular space; intercellular bridge; nuclear membrane; mitochondrion; endoplasmic reticulum; cytoplasm; extracellular region; nucleolus. Molecular Function: protein binding; serine-type endopeptidase activity. Biological Process: myelination; protein autoprocessing; collagen catabolic process; central nervous system development; amyloid precursor protein metabolic process; tissue regeneration; regulation of cell differentiation; positive regulation of G-protein coupled receptor protein signaling pathway; response to wounding; hormone metabolic process; protein processing; proteolysis

48-Strip-Wells

470 USD

96-Strip-Wells

675