catalog number :
MBS721575
products type :
ELISA Kit
products full name :
Rat Dihydropyrimidine Dehydrogenase ELISA Kit
products short name :
Dihydropyrimidine Dehydrogenase
other names :
dihydropyrimidine dehydrogenase; Dihydropyrimidine dehydrogenase [NADP(+)]; dihydropyrimidine dehydrogenase [NADP(+)]; dihydropyrimidine dehydrogenase [NADP(+)]; dihydrouracil dehydrogenase; dihydrothymine dehydrogenase; dihydropyrimidine dehydrogenase; Dihydrothymine dehydrogenase; Dihydrouracil dehydrogenase
products gene name :
DPYD
other gene names :
DPYD; DPYD; DHP; DPD; DHPDHASE; DHPDHase; DPD
uniprot entry name :
DPYD_HUMAN
storage stability :
Store all reagents at 2-8 degree C.
products categories :
Signal Transduction
ncbi acc num :
AAB51366.1
ncbi mol weight :
18,936 Da
ncbi pathways :
Drug Metabolism - Other Enzymes Pathway 83033!!Drug Metabolism - Other Enzymes Pathway 428!!Fluoropyrimidine Activity Pathway 198778!!Metabolic Pathways 132956!!Metabolism Pathway 477135!!Metabolism Of Nucleotides Pathway 106263!!Pantothenate And CoA Biosynthesis Pathway 83015!!Pantothenate And CoA Biosynthesis Pathway 401!!Pyrimidine Catabolism Pathway 106288!!Pyrimidine Degradation, Uracil = Beta-alanine, Thymine = 3-aminoisobutanoate Pathway 605866
ncbi summary :
The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]