catalog number :
MBS7213177
products type :
ELISA Kit
products full name :
Human 1, 2 dihydroxy 3 keto 5 methylthiopentene dioxygenase (ADI1) ELISA Kit
products short name :
1, 2 dihydroxy 3 keto 5 methylthiopentene dioxygenase (ADI1)
other names :
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; submergence induced protein 2; submergence-induced protein-like factor; MT1-MMP cytoplasmic tail-binding protein-1; acireductone dioxygenase (Fe(2+)-requiring); acireductone dioxygenase (Ni(2+)-requiring); membrane-type 1 matrix metalloproteinase cytoplasmic tail binding protein-1; acireductone dioxygenase 1; Acireductone dioxygenase (Fe(2+)-requiring); ARD; Fe-ARD; Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein 1; MTCBP-1; Submergence-induced protein-like factor; Sip-L
other gene names :
ADI1; ADI1; ARD; APL1; SIPL; mtnD; Fe-ARD; MTCBP1; Ni-ARD; HMFT1638; MTCBP1; HMFT1638; ARD; Fe-ARD; MTCBP-1; Sip-L
uniprot entry name :
MTND_HUMAN
storage stability :
Store all reagents at 2-8 degree C.
products categories :
Signal Transduction
ncbi mol weight :
20,332 Da
ncbi pathways :
Cysteine And Methionine Metabolism Pathway (104488); Cysteine And Methionine Metabolism Pathway (103421); Metabolic Pathways (132956); Metabolism Pathway (477135); Metabolism Of Amino Acids And Derivatives Pathway (106169); Metabolism Of Polyamines Pathway (106193); Methionine Salvage Pathway (413446); Methionine Salvage Pathway (366245); Methionine Salvage Pathway (468227); S-methyl-5-thio-alpha-D-ribose 1-phosphate Degradation Pathway (547487)
ncbi summary :
This gene encodes an enzyme that belongs to the aci-reductone dioxygenase family of metal-binding enzymes, which are involved in methionine salvage. This enzyme may regulate mRNA processing in the nucleus, and may carry out different functions depending on its localization. Related pseudogenes have been defined on chromosomes 8 and 20. [provided by RefSeq, May 2010]
uniprot summary :
ADI1: Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line. Belongs to the acireductone dioxygenase (ARD) family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: EC 1.13.11.54; Oxidoreductase; Amino Acid Metabolism - cysteine and methionine. Chromosomal Location of Human Ortholog: 2p25.3. Cellular Component: nucleoplasm; Golgi apparatus; cytoplasm; plasma membrane; cytosol; nucleus. Molecular Function: acireductone dioxygenase [iron(II)-requiring] activity; protein binding; iron ion binding; oxidoreductase activity. Biological Process: methionine salvage; sulfur amino acid metabolic process; polyamine metabolic process