catalog number :
MBS7212481
products type :
ELISA Kit
products full name :
Mouse Adipocyte enhancer-binding protein 1 (AEBP1) ELISA Kit
products short name :
Adipocyte enhancer-binding protein 1 (AEBP1)
other names :
adipocyte enhancer-binding protein 1; Adipocyte enhancer-binding protein 1; adipocyte enhancer-binding protein 1; aortic carboxypeptidase-like protein; AE binding protein 1; Aortic carboxypeptidase-like protein
products gene name :
AEBP1
other gene names :
AEBP1; AEBP1; ACLP; ACLP; AE-binding protein 1
uniprot entry name :
AEBP1_HUMAN
storage stability :
Store all reagents at 2-8 degree C.
products categories :
Epigenetics and Nuclear Signaling
ncbi acc num :
NP_001120.3
ncbi gb acc num :
NM_001129.4
ncbi mol weight :
82,183 Da
ncbi summary :
This gene encodes a member of carboxypeptidase A protein family. The encoded protein may function as a transcriptional repressor and play a role in adipogenesis and smooth muscle cell differentiation. Studies in mice suggest that this gene functions in wound healing and abdominal wall development. Overexpression of this gene is associated with glioblastoma. [provided by RefSeq, May 2013]
uniprot summary :
AEBP1: May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I- kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor. Belongs to the peptidase M14 family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Secreted, signal peptide; Transcription factor. Chromosomal Location of Human Ortholog: 7p13. Cellular Component: extracellular matrix; extracellular space; cytoplasm; nucleus. Molecular Function: calmodulin binding; carboxypeptidase activity; zinc ion binding; transcription factor activity; metallocarboxypeptidase activity; transcription corepressor activity. Biological Process: muscle development; transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; proteolysis; skeletal development