catalog number :
MBS721070
products type :
ELISA Kit
products full name :
Mouse Catechol-O-Metthyhransferase ELSA ELISA Kit
products short name :
Catechol-O-Metthyhransferase ELSA
other names :
COMT; Catechol O-methyltransferase; catechol O-methyltransferase; epididymis secretory sperm binding protein Li 98n; catechol-O-methyltransferase
products gene name :
COMT
other gene names :
COMT; COMT; HEL-S-98n
uniprot entry name :
COMT_HUMAN
storage stability :
Store all reagents at 2-8 degree C.
other info2 :
ELISA Method: Competitive. Highest Standards: 10ng/mL. Concentration of Standards: Concentration of Standards: 0,0.5,1.0,2.5,5.0,10ng/mL
ncbi acc num :
CAG30308.1
ncbi mol weight :
24,449 Da
ncbi pathways :
Biogenic Amine Synthesis Pathway 198793!!Biological Oxidations Pathway 105698!!Dopamine Clearance From The Synaptic Cleft Pathway 106527!!Dopamine Metabolism Pathway 920995!!Dopaminergic Synapse Pathway 469199!!Dopaminergic Synapse Pathway 469185!!Enzymatic Degradation Of Dopamine By Monoamine Oxidase Pathway 106529!!Enzymatic Degradation Of Dopamine By COMT Pathway 106528!!Estrogen Metabolism Pathway 198898!!L-dopa Degradation Pathway 545339
ncbi summary :
Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008]