catalog number :
MBS720825
products type :
ELISA Kit
products full name :
Mouse Nicotinic acetylcholine receptor ELISA Kit
products short name :
Nicotinic acetylcholine receptor
other names :
nicotinic acetylcholine receptor, partial; Neuronal acetylcholine receptor subunit alpha-4; neuronal acetylcholine receptor subunit alpha-4; cholinergic receptor, nicotinic, alpha polypeptide 4; neuronal nicotinic acetylcholine receptor alpha-4 subunit; cholinergic receptor, nicotinic, alpha 4 (neuronal)
products gene name :
N-AChR
other gene names :
CHRNA4; CHRNA4; EBN; BFNC; EBN1; NACHR; NACRA4; NACHRA4; NACRA4
uniprot entry name :
ACHA4_HUMAN
storage stability :
Store all reagents at 2-8 degree C.
products categories :
Neurobiology
ncbi acc num :
CAA60959.1
ncbi mol weight :
60,994 Da
ncbi pathways :
Acetylcholine Binding And Downstream Events Pathway 106535!!Activation Of Nicotinic Acetylcholine Receptors Pathway 161027!!Cholinergic Synapse Pathway 217716!!Highly Calcium Permeable Nicotinic Acetylcholine Receptors Pathway 161029!!Highly Calcium Permeable Postsynaptic Nicotinic Acetylcholine Receptors Pathway 161032!!Highly Sodium Permeable Acetylcholine Nicotinic Receptors Pathway 161030!!Neuroactive Ligand-receptor Interaction Pathway 83053!!Neuroactive Ligand-receptor Interaction Pathway 462!!Neuronal System Pathway 106513!!Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Pathway 106534
ncbi summary :
This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]