Human Cyclic nucleotide gated cation channel beta 3 (CNGB3) ELISA Kit | MyBioSource MBS7206890 product information

product summary

company name :

MyBioSource

product type :

ELISA/assay

product name :

Human Cyclic nucleotide gated cation channel beta 3 (CNGB3) ELISA Kit

catalog :

MBS7206890

quantity :

48-Strip-Wells

price :

440 USD

more info or order :

MyBioSource product webpage

image

image 1 :

product information

catalog number :

MBS7206890

products type :

ELISA Kit

products full name :

Human Cyclic nucleotide gated cation channel beta 3 (CNGB3) ELISA Kit

products short name :

[Cyclic nucleotide gated cation channel beta 3 (CNGB3)]

products name syn :

[Human Cyclic nucleotide gated cation channel b 3 (CNGB3) ELISA Kit]

other names :

[cyclic nucleotide-gated cation channel beta-3; Cyclic nucleotide-gated cation channel beta-3; cyclic nucleotide-gated cation channel beta-3; CNG channel beta-3; cone photoreceptor cGMP-gated cation channel beta-subunit; cyclic nucleotide-gated cation channel modulatory subunit; cyclic nucleotide gated channel beta 3; Cone photoreceptor cGMP-gated channel subunit beta; Cyclic nucleotide-gated cation channel modulatory subunit; Cyclic nucleotide-gated channel beta-3; CNG channel beta-3]

products gene name :

[CNGB3]

products gene name syn :

[CNGB3]

other gene names :

[CNGB3; CNGB3; ACHM1; CNG channel beta-3]

uniprot entry name :

CNGB3_HUMAN

reactivity :

Human

specificity :

This assay has high sensitivity and excellent specificity for detection of CNGB3. No significant cross-reactivity or interference between CNGB3 and analogues was observed. NOTE: Limited by current skills and knowledge, it is impossible for us to complete the cross-reactivity detection between CNGB3 and all the analogues, therefore, cross reaction may still exist in some cases.

storage stability :

Store all reagents at 2-8 degree C.

image1 heading :

Typical Testing Data/Standard Curve (for reference only)

other info1 :

Samples: Serum, plasma, cell culture supernatants, body fluid and tissue homogenate. Sensitivity: 0.1 ng/mL

products categories :

Neurobiology

products description :

Intended Uses: This CNGB3 ELISA kit is a 1.5 hour solid-phase ELISA designed for the quantitative determination of Human CNGB3. This ELISA kit for research use only, not for therapeutic or diagnostic applications!

ncbi gi num :

116642889

ncbi acc num :

NP_061971.3

ncbi gb acc num :

NM_019098.4

ncbi mol weight :

91,633 Da

ncbi pathways :

Visual Signal Transduction: Cones Pathway (137926); CAMP Signaling Pathway (1017634); CAMP Signaling Pathway (1019520)

ncbi summary :

This gene encodes the beta subunit of a cyclic nucleotide-gated ion channel. The encoded beta subunit appears to play a role in modulation of channel function in cone photoreceptors. This heterotetrameric channel is necessary for sensory transduction, and mutations in this gene have been associated with achromatopsia 3, progressive cone dystrophy, and juvenile macular degeneration, also known as Stargardt Disease. [provided by RefSeq, Feb 2010]

uniprot summary :

CNGB3: Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficiency of the channel when coexpressed with CNGA3. Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones. Defects in CNGB3 are the cause of Stargardt disease type 1 (STGD1). STGD is one of the most frequent causes of macular degeneration in childhood. It is characterized by macular dystrophy with juvenile-onset, rapidly progressive course, alterations of the peripheral retina, and subretinal deposition of lipofuscin-like material. STGD1 inheritance is autosomal recessive. Defects in CNGB3 are the cause of achromatopsia type 3 (ACHM3); also known as Pingelapese blindness. ACHM3 is a congenital complete achromatopsia and is distinct from total colorblindness mainly because of the consistent concurrence of severe myopia. Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGB3 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, cation. Chromosomal Location of Human Ortholog: 8q21.3. Cellular Component: photoreceptor outer segment; integral to plasma membrane. Molecular Function: voltage-gated potassium channel activity; intracellular cAMP activated cation channel activity; intracellular cGMP activated cation channel activity; cGMP binding. Biological Process: phototransduction, visible light; regulation of membrane potential; visual perception; transport; signal transduction; cation transport. Disease: Achromatopsia 3; Stargardt Disease 1

size1 :

48-Strip-Wells

price1 :

440 USD

size2 :

96-Strip-Wells

price2 :

640

size3 :

5x96-Strip-Wells

price3 :

2895

size4 :

10x96-Strip-Wells

price4 :

5415

more info or order :

MyBioSource product webpage