ELISA/assay

Rat azurocidin ELISA Kit

MBS720406

96 Strip Wells

675 USD

ELISA Kit

Rat azurocidin ELISA Kit

azurocidin

Rat azurocidin ELISA Kit; azurocidin; azurocidin (Rat)

azurocidin preproprotein; Azurocidin; azurocidin; neutrophil azurocidin; heparin-binding protein; cationic antimicrobial protein 37; cationic antimicrobial protein CAP37; azurocidin 1; Cationic antimicrobial protein CAP37; Heparin-binding protein

AZU

AZU1; AZU1; AZU; HBP; NAZC; AZAMP; CAP37; HUMAZUR

CAP7_HUMAN

Rat

Store all reagents at 2-8 degree C

Rat ELISA Kit

11342670

NP_001691.1

NM_001700.3

P20160

26,886 Da

Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of microorganisms. The protein encoded by this gene is an azurophil granule antibiotic protein, with monocyte chemotactic and antibacterial activity. It is also an important multifunctional inflammatory mediator. This encoded protein is a member of the serine protease gene family but it is not a serine proteinase, because the active site serine and histidine residues are replaced. The genes encoding this protein, neutrophil elastase 2, and proteinase 3 are in a cluster located at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq]

Function: This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Acting alone, it does not have antimicrobial activity against the Gram-negative bacteria A.actinomycetemcomitans ATCC 29532, A.actinomycetemcomitans NCTC 9709, A.actinomycetemcomitans FDC-Y4, H.aphrophilus ATCC 13252, E.corrodens ATCC 23834, C.sputigena ATCC 33123, Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872 or E.coli ML-35. Has antibacterial activity against C.sputigena ATCC 33123 when acting synergistically with either elastase or cathepsin G. Ref.10 Ref.14. Subunit structure: Monomer. Subcellular location: Cytoplasmic granule. Note: Cytoplasmic granules of neutrophils. Sequence similarities: Belongs to the peptidase S1 family. Elastase subfamily.Contains 1 peptidase S1 domain.

96 Strip Wells

675 USD