Rabbit anti-human Urokinase-type plasminogen activator polyclonal Antibody | MyBioSource MBS719744 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit anti-human Urokinase-type plasminogen activator polyclonal Antibody

catalog :

MBS719744

quantity :

0.05 mg

price :

160 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS719744

products type :

Antibody

products full name :

Rabbit anti-human Urokinase-type plasminogen activator polyclonal Antibody

products short name :

Urokinase-type plasminogen activator

products name syn :

U-plasminogen activator; uPA; PLAU

other names :

urokinase-type plasminogen activator isoform 2; Urokinase-type plasminogen activator; urokinase-type plasminogen activator; plasminogen activator, urokinase

other gene names :

PLAU; PLAU; ATF; QPD; UPA; URK; u-PA; BDPLT5; U-plasminogen activator; uPA

uniprot entry name :

UROK_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

sequence length :

414

purity :

Caprylic Acid Ammonium Sulfate Precipitation Purified

storage stability :

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

tested application :

ELISA (EIA), Immunohistochemistry (IHC)

other info1 :

Storage Buffer: Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. Conjugate: Non-conjugated

other info2 :

Immunogen: Recombinant human Urokinase-type plasminogen activator protein

products description :

Specifically cleave the zymogen plasminogen to form the active enzyme plasmin.

ncbi gi num :

222537759

ncbi acc num :

NP_001138503.1

ncbi gb acc num :

NM_001145031.2

uniprot acc num :

P00749

ncbi mol weight :

46,908 Da

ncbi pathways :

ATF-2 Transcription Factor Network Pathway (138006); Blood Clotting Cascade Pathway (198840); Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); DNA Damage Response (only ATM Dependent) Pathway (198827); Dissolution Of Fibrin Clot Pathway (1269372); E2F Transcription Factor Network Pathway (137934); Endochondral Ossification Pathway (198812); FGF Signaling Pathway (137989)

ncbi summary :

This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA). HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA). This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimer's disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

uniprot summary :

uPA: Specifically cleave the zymogen plasminogen to form the active enzyme plasmin. Defects in PLAU are the cause of Quebec platelet disorder (QPD). QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins. Belongs to the peptidase S1 family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Motility/polarity/chemotaxis; EC 3.4.21.73; Protease; Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 10q22.2. Cellular Component: cell surface; extracellular region; extracellular space; focal adhesion; plasma membrane. Molecular Function: protein binding; serine-type endopeptidase activity. Biological Process: angiogenesis; blood coagulation; chemotaxis; embryo implantation; fibrinolysis; positive regulation of cell proliferation; positive regulation of smooth muscle cell migration; proteolysis; regulation of cell adhesion mediated by integrin; regulation of receptor activity; regulation of smooth muscle cell migration; response to activity; response to hyperoxia; signal transduction; skeletal muscle regeneration; smooth muscle cell migration; spermatogenesis. Disease: Alzheimer Disease; Quebec Platelet Disorder

size1 :

0.05 mg

price1 :

160 USD

size2 :

0.1 mg

price2 :

235

more info or order :

MyBioSource product webpage