secondary antibody

Rabbit anti-Human IgG Fc fragment polyclonal Antibody, HRP conjugated

MBS719658

0.5 mg

160 USD

Secondary Antibody

Rabbit anti-Human IgG Fc fragment polyclonal Antibody, HRP conjugated

[IgG Fc fragment]

[Fragment crystallizable region]

[IgG]

Polyclonal

IgG

Rabbit

Human

Caprylic Acid Ammonium Sulfate Precipitation purified

Liquid

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

ELISA (EIA), Western Blot (WB)

Recommended dilution: WB:1:500-1:5000

Western Blot (WB)

Immunogen: Human IgG Fc fragment. Storage Buffer: Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

The fragment crystallizable region (Fc region) is the tail region of an antibody that interacts with cell surface receptors called Fc receptors and some proteins of the complement system. This property allows antibodies to activate the immune system. InIgG, IgA and IgD antibody isotypes, the Fc region is composed of two identical protein fragments, derived from the second and third constant domains of the antibody two heavy chains; IgM and IgE Fc regions contain three heavy chain constant domains (CH domains 2-4) in each polypeptide chain. The Fc regions of IgGs bear a highly conserved N-glycosylation site. Glycosylation of the Fc fragment is essential for Fc receptor-mediated activity. The N-glycans attached to this site are predominantly core-fucosylated diantennary structures of the complex type. In addition, small amounts of these N-glycans also bear bisecting GlcNAc and alpha-2,6 linked sialic acid residues.

This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008]

FCGR2A: low affinity receptor for the Fc region of IgGs. Binding to IgG initiates cellular responses against pathogens and soluble antigens. A type I membrane protein found on monocytes, neutrophils and platelets. SHP-1 associates with this protein to modulate signaling events in myeloid cells. Protein type: Cell surface; Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 1q23. Cellular Component: plasma membrane; integral to membrane. Molecular Function: IgG binding. Biological Process: innate immune response. Disease: Systemic Lupus Erythematosus; Malaria, Susceptibility To

0.5 mg

160 USD