Rabbit anti-human GTPase KRas polyclonal Antibody, Biotin conjugated | MyBioSource MBS719647 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit anti-human GTPase KRas polyclonal Antibody, Biotin conjugated

catalog :

MBS719647

quantity :

0.05 mg

price :

160 USD

clonality :

polyclonal

host :

rabbit

conjugate :

biotin

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS719647

products type :

Antibody

products full name :

Rabbit anti-human GTPase KRas polyclonal Antibody, Biotin conjugated

products short name :

GTPase KRas

products name syn :

K-Ras 2; Ki-Ras; c-K-ras; c-Ki-ras; KRAS; KRAS2; RASK2

other names :

GTPase KRas isoform b; GTPase KRas; GTPase KRas; Kirsten rat sarcoma viral oncogene homolog; K-Ras 2; Ki-Ras; c-K-ras; c-Ki-ras

other gene names :

KRAS; KRAS; NS; NS3; CFC2; RALD; KRAS1; KRAS2; RASK2; KI-RAS; C-K-RAS; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; KRAS2; RASK2

uniprot entry name :

RASK_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

sequence length :

188

purity :

Caprylic Acid Ammonium Sulfate Precipitation Purified

storage stability :

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

tested application :

Western Blot (WB), ELISA (EIA)

other info1 :

Storage Buffer: Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. Conjugate: Biotin

other info2 :

Immunogen: Recombinant human GTPase KRas protein

products description :

Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.

ncbi gi num :

15718761

ncbi acc num :

NP_004976.2

ncbi gb acc num :

NM_004985.4

uniprot acc num :

P01116

ncbi mol weight :

21,425 Da

ncbi pathways :

AGE-RAGE Signaling Pathway In Diabetic Complications (1319988); AGE-RAGE Signaling Pathway In Diabetic Complications (1319775); ARMS-mediated Activation Pathway (1269471); Activation Of RAS In B Cells Pathway (1269187); Acute Myeloid Leukemia Pathway (83117); Acute Myeloid Leukemia Pathway (529); Adaptive Immune System Pathway (1269171); Alcoholism Pathway (585563); Alcoholism Pathway (587116); Aldosterone-regulated Sodium Reabsorption Pathway (130626)

ncbi summary :

This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq, Jul 2008]

uniprot summary :

KRas: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Interacts with PHLPP. Interacts (active GTP-bound form preferentially) with RGS14. Alternate between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase- activating protein (GAP). Belongs to the small GTPase superfamily. Ras family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: G protein, monomeric; G protein; Motility/polarity/chemotaxis; G protein, monomeric, Ras; Oncoprotein. Chromosomal Location of Human Ortholog: 12p12.1. Cellular Component: cytoplasm; cytosol; extrinsic to internal side of plasma membrane; focal adhesion; lipid raft; membrane; mitochondrion; plasma membrane. Molecular Function: GDP binding; GMP binding; GTP binding; LRR domain binding; protein binding; protein complex binding. Biological Process: actin cytoskeleton organization and biogenesis; activation of MAPKK activity; activation of NF-kappaB transcription factor; axon guidance; blood coagulation; cytokine and chemokine mediated signaling pathway; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; forebrain astrocyte development; homeostasis of number of cells within a tissue; innate immune response; insulin receptor signaling pathway; leukocyte migration; MAPKKK cascade; negative regulation of cell differentiation; negative regulation of neuron apoptosis; nerve growth factor receptor signaling pathway; positive regulation of cell proliferation; positive regulation of MAP kinase activity; positive regulation of nitric-oxide synthase activity; positive regulation of protein amino acid phosphorylation; positive regulation of Rac protein signal transduction; Ras protein signal transduction; regulation of long-term neuronal synaptic plasticity; regulation of synaptic transmission, GABAergic; response to glucocorticoid stimulus; response to mineralocorticoid stimulus; small GTPase mediated signal transduction; social behavior; stimulatory C-type lectin receptor signaling pathway; striated muscle cell differentiation; vascular endothelial growth factor receptor signaling pathway; visual learning. Disease: Bladder Cancer; Breast Cancer; Cardiofaciocutaneous Syndrome 2; Gastric Cancer, Hereditary Diffuse; Leukemia, Acute Myeloid; Lung Cancer; Noonan Syndrome 3; Pancreatic Cancer; Schimmelpenning-feuerstein-mims Syndrome

size1 :

0.05 mg

price1 :

160 USD

size2 :

0.1 mg

price2 :

235

more info or order :

MyBioSource product webpage