Rabbit anti-human myosin, heavy chain 11, smooth muscle polyclonal Antibody | MyBioSource MBS719273 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit anti-human myosin, heavy chain 11, smooth muscle polyclonal Antibody

catalog :

MBS719273

quantity :

0.05 mL

price :

375 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS719273

products type :

Antibody

products full name :

Rabbit anti-human myosin, heavy chain 11, smooth muscle polyclonal Antibody

products short name :

myosin, heavy chain 11, smooth muscle

products name syn :

myosin; heavy chain 11; smooth muscle; MYH11; AAT4; DKFZp686D10126; DKFZp686D19237; FAA4; FLJ35232; MGC126726; MGC32963; SMHC; SMMHC

other names :

Myosin, heavy chain 11, smooth muscle; Myosin-11; myosin-11; myosin heavy chain 11; myosin heavy chain, smooth muscle isoform; myosin, heavy polypeptide 11, smooth muscle; myosin, heavy chain 11, smooth muscle; Myosin heavy chain 11; Myosin heavy chain, smooth muscle isoform; SMMHC

other gene names :

MYH11; MYH11; AAT4; FAA4; SMHC; SMMHC; KIAA0866

uniprot entry name :

MYH11_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

1945

purity :

Antigen Affinity Purified

tested application :

ELISA (EIA), Western Blot (WB)

other info1 :

Immunogen: Human MYH11

other info2 :

Storage Buffer: PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.

ncbi gi num :

219521495

ncbi acc num :

AAI43365.1

ncbi mol weight :

223,577 Da

ncbi pathways :

Axon Guidance Pathway (105688); Developmental Biology Pathway (477129); EPH-Ephrin Signaling Pathway (1016174); EPHA-mediated Growth Cone Collapse Pathway (1016175); Muscle Contraction Pathway (106261); Sema4D In Semaphorin Signaling Pathway (119520); Sema4D Induced Cell Migration And Growth-cone Collapse Pathway (119522); Semaphorin Interactions Pathway (119519); Smooth Muscle Contraction Pathway (161025); Tight Junction Pathway (83071)

ncbi summary :

The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. The pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

uniprot summary :

MYH11: Muscle contraction. A chromosomal aberration involving MYH11 is found in acute myeloid leukemia of M4EO subtype. Pericentric inversion inv(16)(p13;q22). The inversion produces a fusion protein consisting of the 165 N-terminal residues of CBF-beta (PEPB2) and the tail region of MYH11. Defects in MYH11 are the cause of familial aortic aneurysm thoracic type 4 (AAT4); also known as familial thoracic aortic aneurysm and dissection (TAAD). Aneurysms and dissections of the aorta usually result from degenerative changes in the aortic wall. Thoracic aortic aneurysms and dissections are primarily associated with a characteristic histologic appearance known as medial necrosis or Erdheim cystic medial necrosis in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance. Patients with AAT4 show marked aortic stiffness. Pathological aortas show large areas of medial degeneration with very low smooth muscle cells content. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Motor; Oncoprotein; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 16p13.11. Cellular Component: smooth muscle contractile fiber; stress fiber; melanosome; muscle myosin complex; cytosol. Molecular Function: actin filament binding; calmodulin binding; protein binding; structural constituent of muscle; motor activity; ATP binding. Biological Process: muscle thick filament assembly; axon guidance; elastic fiber assembly; smooth muscle contraction; muscle contraction; cardiac muscle fiber development; metabolic process; ephrin receptor signaling pathway. Disease: Aortic Aneurysm, Familial Thoracic 4

size1 :

0.05 mL

price1 :

375 USD

size2 :

0.15 mL

price2 :

715

more info or order :

MyBioSource product webpage