catalog number :
MBS718882
products type :
Recombinant Protein
products full name :
Recombinant Human 10 kDa heat shock protein, mitochondrial
products short name :
10 kDa heat shock protein
products name syn :
10 kDa chaperonin; Chaperonin 10; CPN10; Early-pregnancy factor; EPF
other names :
10 kDa heat shock protein, mitochondrial; 10 kDa heat shock protein, mitochondrial; 10 kDa heat shock protein, mitochondrial; heat shock protein family E (Hsp10) member 1; 10 kDa chaperonin; Chaperonin 10; CPN10; Early-pregnancy factor; EPF
products gene name :
HSPE1
other gene names :
HSPE1; HSPE1; EPF; CPN10; GROES; HSP10; Hsp10; CPN10; EPF
uniprot entry name :
CH10_HUMAN
sequence positions :
2-102
sequence :
AGQAFRKFLPLFDRVLVERSAAETVTKGGIMLPEKSQGK
VLQATVVAVGSGSKGKGGEIQPVSVKVGDKVLLPEYGGT
KVVLDDKDYFLFRDGDILGKYVD
purity :
Greater than 90% as determined by SDS-PAGE.
storage stability :
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
products categories :
Neuroscience
products description :
Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.
products references :
Identification and cloning of human chaperonin 10 homologue.Monzini N., Legname G., Marcucci F., Gromo G., Modena D.Biochim. Biophys. Acta 1218:478-480(1994)
ncbi acc num :
NP_002148.1
ncbi gb acc num :
NM_002157.2
ncbi summary :
This gene encodes a major heat shock protein which functions as a chaperonin. Its structure consists of a heptameric ring which binds to another heat shock protein in order to form a symmetric, functional heterodimer which enhances protein folding in an ATP-dependent manner. This gene and its co-chaperonin, HSPD1, are arranged in a head-to-head orientation on chromosome 2. Naturally occurring read-through transcription occurs between this locus and the neighboring locus MOBKL3.[provided by RefSeq, Feb 2011]
uniprot summary :
HSPE1: Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. Belongs to the GroES chaperonin family. Protein type: Mitochondrial. Chromosomal Location of Human Ortholog: 2q33.1. Cellular Component: membrane; mitochondrial matrix; mitochondrion. Molecular Function: ATP binding; chaperone binding; protein binding; unfolded protein binding. Biological Process: caspase activation; osteoblast differentiation; protein folding; response to unfolded protein