catalog number :
MBS718782
products type :
Recombinant Protein
products full name :
Recombinant Human Claudin-2 (CLDN2)
products short name :
Claudin-2 (CLDN2)
products name syn :
Recombinant Claudin-2 (CLDN2); Claudin-2; SP82
other names :
claudin-2; Claudin-2; claudin-2; SP82; claudin 2; SP82
products gene name syn :
CLDN2; PSEC0059, SP82, UNQ705/PRO1356
other gene names :
CLDN2; CLDN2
uniprot entry name :
CLD2_HUMAN
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
29-81
form :
Liquid containing glycerol; lyophilization may be available upon request.
storage stability :
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
other info1 :
Species: Homo sapiens (Human)
ncbi acc num :
NP_001164563.1
ncbi gb acc num :
NM_001171092.1
ncbi mol weight :
24,549 Da
ncbi pathways :
Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Cell Junction Organization Pathway (160966); Cell-Cell Communication Pathway (477132); Cell-cell Junction Organization Pathway (119532); Hepatitis C Pathway (173973); Hepatitis C Pathway (173907); Leukocyte Transendothelial Migration Pathway (83083); Leukocyte Transendothelial Migration Pathway (494); Tight Junction Pathway (83071)
ncbi summary :
This gene product belongs to the claudin protein family whose members have been identified as major integral membrane proteins localized exclusively at tight junctions. Claudins are expressed in an organ-specific manner and regulate tissue-specific physiologic properties of tight junctions. This protein is expressed in the intestine. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene.[provided by RefSeq, Jan 2010]
uniprot summary :
Function: Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity . By similarity. Subunit structure: Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN3, but not CLDN1, homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3 . By similarity. Subcellular location: Cell junction tight junction . By similarity. Cell membrane; Multi-pass membrane protein . By similarity. Sequence similarities: Belongs to the claudin family.