Recombinant Human 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (HSD3B1) | MyBioSource MBS718727 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (HSD3B1)

catalog :

MBS718727

quantity :

1 mg (E Coli Derived

price :

1375 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS718727

products type :

Recombinant Protein

products full name :

Recombinant Human 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (HSD3B1)

products short name :

3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (HSD3B1)

products name syn :

Recombinant 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (HSD3B1); 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I; 3-beta-HSD I Trophoblast antigen FDO

other names :

3 beta-hydroxysteroid dehydrogenase/Delta 5-- 4-isomerase type 1; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1; 3 beta-hydroxysteroid dehydrogenase/Delta 5-- 4-isomerase type 1; 3-beta-HSD I; progesterone reductase; steroid Delta-isomerase; trophoblast antigen FDO161G; delta-5-3-ketosteroid isomerase; 3-beta-hydroxy-5-ene steroid dehydrogenase; 3-beta-hydroxy-Delta(5)-steroid dehydrogenase; short chain dehydrogenase/reductase family 11E, member 1; 3 beta-hydroxysteroid dehydrogenase/Delta 5-- 4-isomerase type I; hydroxy-delta-5-steroid dehydrogenase, 3 beta-and steroid delta-isomerase 1; hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I; 3-beta-HSD I; Trophoblast antigen FDO161GIncluding the following 2 domains:3-beta-hydroxy-Delta(5)-steroid dehydrogenase (EC:1.1.1.145)Alternative name(s):3-beta-hydroxy-5-ene steroid dehydrogenase; Progesterone reductase

products gene name syn :

HSD3B1; 3BH, HSDB3A

other gene names :

HSD3B1; HSD3B1; I; HSD3B; HSDB3; HSDB3A; SDR11E1; 3BETAHSD; 3BH; HSDB3A; 3-beta-HSD I

uniprot entry name :

3BHS1_HUMAN

host :

E Coli or Yeast

sequence positions :

2-373

sequence length :

373

sequence :

TGWSCLVTGAGGFLGQRIIRLLVKEKELKEIRVLDKAFG
PELREEFSKLQNKTKLTVLEGDILDEPFLKRACQDVSVI
IHTACIIDVFGVTHRESIMNVNVKGTQLLLEACVQASVP
VFIYTSSIEVAGPNSYKEIIQNGHEEEPLENTWPAPYPH
SKKLAEKAVLAANGWNLKNGGTLYTCALRPMYIYGEGSR
FLSASINEALNNNGILSSVGKFSTVNPVYVGNVAWAHIL
ALRALQDPKKAPSIRGQFYYISDDTPHQSYDNLNYTLSK
EFGLRLDSRWSFPLSLMYWIGFLLEIVSFLLRPIYTYRP
PFNRHIVTLSNSVFTFSYKKAQRDLAYKPLYSWEEAKQK
TVEWVGSLVDRHKETLKSKTQ

purity :

>90%

form :

This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.

storage stability :

Store at -20 degree C. For extended storage, store at -20 or -80 degree C.

other info1 :

Tag Information: His tagged. Species: Homo sapiens (Human)

other info2 :

Storage Buffer: PBS pH 7.4, 50% glycerol

ncbi gi num :

4504507

ncbi acc num :

NP_000853.1

ncbi gb acc num :

NM_000862.2

uniprot acc num :

P14060

ncbi mol weight :

42,252 Da

ncbi pathways :

Androgen Biosynthesis Pathway 106154!!C19/C18-Steroid Hormone Biosynthesis, Pregnenolone = Androstenedione = Estrone Pathway 413383!!C19/C18-Steroid Hormone Biosynthesis, Pregnenolone = Androstenedione = Estrone Pathway 468268!!Glucocorticoid Mineralcorticoid Metabolism Pathway 198902!!Glucocorticoid Biosynthesis Pathway 106152!!Metabolism Pathway 477135!!Metabolism Of Lipids And Lipoproteins Pathway 160976!!Metabolism Of Steroid Hormones And Vitamins A And D Pathway 106150!!Mineralocorticoid Biosynthesis Pathway 106153!!Steroid Biosynthesis Pathway 198866

uniprot summary :

Function: 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. Efficiently catalyzes the transformation of pregnenolone to progesterone, 17-alpha-hydroxypregnenolone to 17-alpha-hydroxyprogesterone, DHEA to 4-androstenedione, dihydrotestosterone to 5-alpha-androstane-3 beta,17 beta-diol, dehydroepiandrosterone to androstenedione and 5-alpha-androstan-3 beta,17 beta-diol to 5-alpha-dihydrotestosterone. Ref.2 Ref.6. Catalytic activity: A 3-beta-hydroxy-Delta(5)-steroid + NAD+ = a 3-oxo-Delta(5)-steroid + NADH.A 3-oxo-Delta(5)-steroid = a 3-oxo-Delta(4)-steroid. Pathway: Lipid metabolism; steroid biosynthesis. Subcellular location: Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein. Tissue specificity: Placenta and skin. Predominantly expressed in mammary gland tissue. Sequence similarities: Belongs to the 3-beta-HSD family. Sequence caution: The sequence AAA36001.1 differs from that shown. Reason: Erroneous gene model prediction.

size :

1 mg (E Coli Derived)

price :

1375 USD

more info or order :

MyBioSource product webpage