Recombinant Human Bone morphogenetic protein 7 (BMP7) | MyBioSource MBS718522 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Bone morphogenetic protein 7 (BMP7)

catalog :

MBS718522

quantity :

0.5 mg (E-Coli)

price :

875 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS718522

products type :

Recombinant Protein

products full name :

Recombinant Human Bone morphogenetic protein 7 (BMP7)

products short name :

Bone morphogenetic protein 7 (BMP7)

products name syn :

Bone morphogenetic protein 7; BMP-7; Osteogenic protein 1; OP-1; INN=; Eptotermin alfa

other names :

bone morphogenetic protein 7; Bone morphogenetic protein 7; bone morphogenetic protein 7; osteogenic protein 1; bone morphogenetic protein 7; Osteogenic protein 1; OP-1; INN: Eptotermin alfa

products gene name :

BMP7

products gene name syn :

BMP7; OP1

other gene names :

BMP7; BMP7; OP-1; OP1; BMP-7; OP-1

uniprot entry name :

BMP7_HUMAN

host :

E Coli or Yeast or Baculovirus or Mammalian Cell

sequence positions :

293-431

sequence length :

139

sequence :

STGSKQRS QNRSKTPKNQ EALRMANVAE NSSSDQRQAC KKHELYVSFR DLGWQDWIIA PEGYAAYYCE GECAFPLNSY MNATNHAIVQ TLVHFINPET VPKPCCAPTQ LNAISVLYFD DSSNVILKKY RNMVVRACGC H

purity :

>90%

form :

Liquid containing glycerol; lyophilization may be available upon request.

storage stability :

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

other info1 :

Species: Homo sapiens (Human)

products description :

Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.

ncbi gi num :

4502427

ncbi acc num :

NP_001710.1

ncbi gb acc num :

NM_001719.2

uniprot acc num :

P18075

ncbi mol weight :

49,313 Da

ncbi pathways :

ALK2 Signaling Events Pathway (137983); BMP Receptor Signaling Pathway (137948); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Elastic Fibre Formation Pathway (730310); Endochondral Ossification Pathway (198812); Extracellular Matrix Organization Pathway (576262); Hippo Signaling Pathway (749777); Hippo Signaling Pathway (750388); Molecules Associated With Elastic Fibres Pathway (730311)

ncbi summary :

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development and possible bone inductive activity. [provided by RefSeq, Jul 2008]

uniprot summary :

BMP7: Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis. Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with TWSG1. Expressed in the kidney and bladder. Lower levels seen in the brain. Belongs to the TGF-beta family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 20q13. Cellular Component: extracellular matrix; extracellular space; extracellular region. Molecular Function: heparin binding; protein binding; growth factor activity; cytokine activity; transforming growth factor beta receptor binding. Biological Process: response to peptide hormone stimulus; axon guidance; negative regulation of MAP kinase activity; extracellular matrix organization and biogenesis; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; negative regulation of NF-kappaB import into nucleus; embryonic pattern specification; response to estradiol stimulus; negative regulation of cell cycle; BMP signaling pathway; regulation of apoptosis; response to vitamin D; epithelial cell differentiation; ureteric bud development; dendrite development; mesonephros development; skeletal development; embryonic limb morphogenesis; ossification; positive regulation of heterotypic cell-cell adhesion; positive regulation of bone mineralization; odontogenesis of dentine-containing teeth; positive regulation of osteoblast differentiation; negative regulation of neuron differentiation; mesenchymal cell differentiation; mesoderm formation; branching morphogenesis of a tube; inhibition of NF-kappaB transcription factor; cartilage development; negative regulation of mitosis; negative regulation of Notch signaling pathway; epithelial to mesenchymal transition; negative regulation of phosphorylation; steroid hormone mediated signaling; positive regulation of transcription from RNA polymerase II promoter; embryonic camera-type eye morphogenesis; negative regulation of transcription, DNA-dependent; metanephros development; neurite morphogenesis; growth

size1 :

0.5 mg (E-Coli)

price1 :

875 USD

size2 :

0.05 mg (Baculovirus)

price2 :

875

size3 :

0.5 mg (Yeast)

price3 :

1100

size4 :

0.05 mg (Mammalian-Cell)

price4 :

1100

size5 :

1 mg (E-Coli)

price5 :

1285

more info or order :

MyBioSource product webpage