product summary
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company name :
MyBioSource
product type :
protein
product name :
Recombinant Rat Egl nine homolog 1 (Egln1)
catalog :
MBS718408
quantity :
1 mg (E Coli Derived
price :
1465 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS718408
products type :
Recombinant Protein
products full name :
Recombinant Rat Egl nine homolog 1 (Egln1)
products short name :
Egl nine homolog 1 (Egln1)
other names :
Egl nine homolog 1; Egl nine homolog 1; egl nine homolog 1; HIF-prolyl hydroxylase 2; hypoxia-inducible factor prolyl hydroxylase 2; prolyl hydroxylase domain-containing protein 2; egl-9 family hypoxia-inducible factor 1; Hypoxia-inducible factor prolyl hydroxylase 2; HIF-PH2; HIF-prolyl hydroxylase 2; HPH-2; Prolyl hydroxylase domain-containing protein 2; PHD2
products gene name :
Egln1
other gene names :
Egln1; Egln1; PHD2; HPH-2; PHD-2; HIF-PH2; HIF-PH2; HIF-prolyl hydroxylase 2; HPH-2; PHD2
uniprot entry name :
EGLN1_RAT
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
1-222
sequence length :
222
sequence :
MNKHGICVVD DFLGRETGQQ IGDEVRALHD TGKFTDGQLV SQKSDSSKDI RGDKITWIEG KEPGCETIGL LMSSMDDLIR HCSGKLGNYR INGRTKAMVA CYPGNGTGYV RHVDNPNGDG RCVTCIYYLN KDWDAKVSGG ILRIFPEGKA QFADIEPKFD RLLFFWSDRR NPHEVQPAYA TRYAITVWYF DADERARAKV KYLTGEKGVR VELKPNSVSK DV
purity :
>90%
storage stability :
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
other info1 :
Tag Information: His tagged. Species: Rattus norvegicus (Rat)
other info2 :
Storage Buffer: Tris-based buffer,50% glycerol. Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
ncbi gi num :
32129504
ncbi acc num :
P59722.1
uniprot acc num :
P59722
ncbi mol weight :
24,974 Da
ncbi pathways :
Cellular Response To Hypoxia Pathway 1010375!!Cellular Responses To Stress Pathway 1010374!!HIF-1 Signaling Pathway 695233!!Oxygen-dependent Proline Hydroxylation Of Hypoxia-inducible Factor Alpha Pathway 1010378!!Pathways In Cancer 83493!!Regulation Of Hypoxia-inducible Factor (HIF) By Oxygen Pathway 1010376!!Renal Cell Carcinoma Pathway 83495!!Renal Cell Carcinoma Pathway 519
ncbi summary :
This gene encodes a component of a transcriptional complex that plays a central role in mammalian oxygen homeostasis. Hypoxia reduces the activity of prolyl hyxroxylases that hydroxylate specific proline residues of the hypoxia-inducible factor-1a (Hif1a). In the absence of hydroxylation, the Hif1a transcription factor accumulates and activates transcription of hypoxia-responsive target genes. This gene encodes one of the three known Hif-interacting 2-oxoglutarate/iron-dependent prolyl-hydroxylases (HIF-PHDs) in rat. Targeted disruption of this gene in mice produced embryonic lethality between embryonic day 12.5 and day 14.5. Based on the transcript data currently available for rat, this Reference Sequence is believed to contain the complete coding region for this gene. However, when compared to its mouse and human orthologs, it has a shorter 5' coding region and an incomplete N-terminus zf-MYND domain. This locus currently has limited transcript data and aligns to an unfinished region of the rat reference genome assembly. It is therefore uncertain whether its coding region can be extended at the 5' end to encode a complete zf-MYND domain, whether no further changes need to be made to its coding region, or whether it is a transcribed pseudogene that does not encode a functional protein. As more transcript and experimental data become available, the coding status of this locus may change. [provided by RefSeq, Jul 2008]
size :
1 mg (E Coli Derived)
price :
1465 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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