protein

Recombinant Human Complement receptor type 1 (CR1), partial

MBS717740

0.5 mg (E-Coli)

945 USD

Recombinant Protein

Recombinant Human Complement receptor type 1 (CR1), partial

Complement receptor type 1 (CR1), partial

Complement receptor type 1; C3b/C4b receptor; CD_antigen=; CD35

complement receptor type 1 isoform F; Complement receptor type 1; complement receptor type 1; CD35 antigen; C3b/C4b receptor; C3-binding protein; Knops blood group antigen; complement component (3b/4b) receptor 1 (Knops blood group); C3b/C4b receptor; CD_antigen: CD35

CR1

CR1; C3BR

CR1; CR1; KN; C3BR; C4BR; CD35; C3BR

CR1_HUMAN

E Coli or Yeast or Baculovirus or Mammalian Cell

901-1095

>90%

Liquid containing glycerol; lyophilization may be available upon request.

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Species: Homo sapiens (Human)

CR1; C3BR

86793036

NP_000564.2

NM_000573.3

P17927

223,663 Da

Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489); Leishmaniasis Pathway (144181); Leishmaniasis Pathway (144028); Malaria Pathway (152665); Malaria Pathway (152657); Tuberculosis Pathway (213780)

This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. [provided by RefSeq, Jul 2008]

CR1: Mediates cellular binding of particles and immune complexes that have activated complement. Belongs to the receptors of complement activation (RCA) family. Protein type: Receptor, misc.; Membrane protein, integral. Chromosomal Location of Human Ortholog: 1q32. Cellular Component: cell surface; integral to plasma membrane; plasma membrane. Molecular Function: complement component C4b binding; complement component C3b receptor activity; complement component C4b receptor activity; complement component C3b binding. Biological Process: negative regulation of complement activation, alternative pathway; complement receptor mediated signaling pathway; negative regulation of complement activation, classical pathway; regulation of complement activation; innate immune response; complement activation, classical pathway. Disease: Knops Blood Group System; Malaria, Susceptibility To

0.5 mg (E-Coli)

945 USD

0.05 mg (Baculovirus)

945

0.5 mg (Yeast)

1165

0.05 mg (Mammalian-Cell)

1165

1 mg (E-Coli)

1390