catalog number :
MBS717717
products type :
Recombinant Protein
products full name :
Recombinant Mouse Alpha-fetoprotein
products short name :
Alpha-fetoprotein
products name syn :
Alpha-1-fetoprotein; Alpha-fetoglobulin
other names :
alpha-fetoprotein; Alpha-fetoprotein; alpha-fetoprotein; alpha fetoprotein; Alpha-1-fetoprotein; Alpha-fetoglobulin
other gene names :
Afp; Afp
uniprot entry name :
FETA_MOUSE
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
19-605, Mature full length protein;
sequence :
KALHENEFGIASTLDSSQCVTEKNVLSIATITFTQFVPE
ATEEEVNKMTSDVLAAMKKNSGDGCLESQLSVFLDEICH
ETELSNKYGLSGCCSQSGVERHQCLLARKKTAPASVPPF
QFPEPAESCKAHEENRAVFMNRFIYEVSRRNPFMYAPAI
LSLAAQYDKVVLACCKADNKEECFQTKRASIAKELREGS
MLNEHVCSVIRKFGSRNLQATTIIKLSQKLTEANFTEIQ
KLALDVAHIHEECCQGNSLECLQDGEKVMTYICSQQNIL
SSKIAECCKLPMIQLGFCIIHAENGVKPEGLSLNPSQFL
GDRNFAQFSSEEKIMFMASFLHEYSRTHPNLPVSVILRI
AKTYQEILEKCSQSGNLPGCQDNLEEELQKHIEESQALS
KQSCALYQTLGDYKLQNLFLIGYTRKAPQLTSAELIDLT
GKMVSIASTCCQLSEEKWSGCGEGMADIFIGHLCIRNEA
SPVNSGISHCCNSSYSNRRLCITSFLRDETYAPPPFSED
KFIFHKDLCQAQGKALQTMKQELLINLVKQKPELTEEQL
AAVTADFSGLLEKCCKAQDQEVCFTEEGPKLISKTRDAL
GV
purity :
Greater than 90% as determined by SDS-PAGE.
form :
Liquid containing glycerol; lyophilization may be available upon request.
storage stability :
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
products description :
Binds estrogens, fatty acids and metals.
products references :
Homology between the primary structure of alpha-fetoprotein, deduced from a complete cDNA sequence, and serum albumin.Law S.W., Dugaiczyk A.Nature 291:201-205(1981)
The rate of molecular evolution of alpha-fetoprotein approaches that of pseudogenes.Minghetti P.P., Law S.W., Dugaiczyk A.Mol. Biol. Evol. 2:347-358(1985)
Intragenic amplification and divergence in the mouse alpha-fetoprotein gene.Eiferman F.A., Young P.R., Scott R.W., Tilghman S.M.Nature 294:713-718(1981)
The evolution of alpha-fetoprotein and albumin. I. A comparison of the primary amino acid sequences of mammalian alpha-fetoprotein and albumin.Gorin M.B., Cooper D.L., Eiferman F.A., van de Rijn P., Tilghman S.M.J. Biol. Chem. 256:1954-1959(1981)
ncbi acc num :
NP_031449.3
ncbi gb acc num :
NM_007423.4
ncbi pathways :
Hippo Signaling Pathway (749786); Hippo Signaling Pathway (750388)
uniprot summary :
AFP: Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties. Dimeric and trimeric forms have been found in addition to the monomeric form. Plasma. Synthesized by the fetal liver and yolk sac. Belongs to the ALB/AFP/VDB family. Protein type: Secreted, signal peptide; Secreted. Cellular Component: cytoplasm; extracellular region; extracellular space. Molecular Function: beta-glucuronidase activity; metal ion binding. Biological Process: ovulation from ovarian follicle; progesterone metabolic process; sexual reproduction; transport