Recombinant Cat Macrophage colony-stimulating factor 1 receptor | MyBioSource MBS717695 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Cat Macrophage colony-stimulating factor 1 receptor

catalog :

MBS717695

quantity :

0.05 mg (E-Coli)

price :

190 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS717695

products type :

Recombinant Protein

products full name :

Recombinant Cat Macrophage colony-stimulating factor 1 receptor

products short name :

Macrophage colony-stimulating factor 1 receptor

products name syn :

CSF-1 receptor (EC:2.7.10.1); CSF-1-R; CSF-1R; M-CSF-R; Proto-oncogene c-Fms; CD_antigen: CD115

other names :

macrophage colony-stimulating factor 1 receptor; Macrophage colony-stimulating factor 1 receptor; macrophage colony-stimulating factor 1 receptor; CSF-1 receptor (EC:2.7.10.1); CSF-1-R; CSF-1R; M-CSF-R; Proto-oncogene c-Fms; CD_antigen: CD115

products gene name :

CSF1R

other gene names :

CSF1R; CSF1R; CSF1; M-CSF; CSF-1R; M-CSF-R; FMS; CSF-1-R; CSF-1R; M-CSF-R

uniprot entry name :

CSF1R_FELCA

host :

E Coli or Yeast or Baculovirus or Mammalian Cell

sequence positions :

20-514

sequence length :

980

sequence :

VPVIQPSGPELVVEPGTTVTLRCVGNGSVEWDGPISPHW
NLDLDPPSSILTTNNATFQNTGTYHCTEPGNPQGGNATI
HLYVKDPARPWKVLAQEVTVLEGQDALLPCLLTDPALEA
GVSLVRVRGRPVLRQTNYSFSPWHGFTIHKAKFIENHVY
QCSARVDGRTVTSMGIWLKVQKDISGPATLTLEPAELVR
IQGEAAQIVCSASNIDVNFDVSLRHGDTKLTISQQSDFH
DNRYQKVLTLNLDHVSFQDAG

purity :

Greater than 90% as determined by SDS-PAGE.

form :

Liquid containing glycerol; lyophilization may be available upon request.

storage stability :

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

products description :

Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hatopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and fale fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding. Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL. Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1. Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2. Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP-1. Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor.

products references :

Activation of the feline c-fms proto-oncogene multiple alterations are required to generate a fully transformed phenotype.Woolford J., McAuliffe A., Rohrschneider L.R.Cell 55:965-977(1988)

ncbi gi num :

57163771

ncbi acc num :

NP_001009231.1

ncbi gb acc num :

NM_001009231.1

uniprot acc num :

P13369

ncbi mol weight :

70.7kD

ncbi pathways :

Cytokine-cytokine Receptor Interaction Pathway (741721); Cytokine-cytokine Receptor Interaction Pathway (460); Endocytosis Pathway (741733); Endocytosis Pathway (102181); Hematopoietic Cell Lineage Pathway (741764); Hematopoietic Cell Lineage Pathway (489); Osteoclast Differentiation Pathway (741749); Osteoclast Differentiation Pathway (193096); PI3K-Akt Signaling Pathway (741738); PI3K-Akt Signaling Pathway (692979)

size1 :

0.05 mg (E-Coli)

price1 :

190 USD

size2 :

0.2 mg (E-Coli)

price2 :

460

size3 :

0.5 mg (E-Coli)

price3 :

750

size4 :

1 mg (E-Coli)

price4 :

1180

size5 :

0.05 mg (Baculovirus)

price5 :

1280

more info or order :

MyBioSource product webpage