product summary
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company name :
MyBioSource
product type :
protein
product name :
Recombinant Human Interleukin-1 receptor type 1 (IL1R1)
catalog :
MBS717686
quantity :
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price :
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more info or order :
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product information
catalog number :
MBS717686
products type :
Recombinant Protein
products full name :
Recombinant Human Interleukin-1 receptor type 1 (IL1R1)
products short name :
Interleukin-1 receptor type 1 (IL1R1)
products name syn :
Interleukin-1 receptor type 1; IL-1R-1; IL-1RT-1; IL-1RT1; CD121 antigen-like family member A; Interleukin-1 receptor alpha; IL-1R-alpha; Interleukin-1 receptor type I; p80; CD_antigen=; CD121aCleaved into the following 2 chains:; 1. Interleukin-1 recepto
other names :
interleukin-1 receptor type 1 isoform 1; Interleukin-1 receptor type 1; interleukin-1 receptor type 1; IL-1R-1; IL-1RT1; IL-1RT-1; interleukin-1 receptor alpha; interleukin-1 receptor type I; CD121 antigen-like family member A; interleukin 1 receptor alpha, type I; interleukin 1 receptor, type I; CD121 antigen-like family member A; Interleukin-1 receptor alpha; IL-1R-alpha; Interleukin-1 receptor type I; p80; CD_antigen: CD121aCleaved into the following 2 chains:Interleukin-1 receptor type 1, membrane form; mIL-1R1; mIL-1RI; Interleukin-1 receptor type 1, soluble form; sIL-1R1; sIL-1RI
products gene name :
IL1R1
products gene name syn :
IL1R1; IL1R; IL1RA; IL1RT1
other gene names :
IL1R1; IL1R1; P80; IL1R; IL1RA; CD121A; D2S1473; IL-1R-alpha; IL1R; IL1RA; IL1RT1; IL-1R-1; IL-1RT-1; IL-1RT1; IL-1R-alpha; mIL-1R1; mIL-1RI; sIL-1R1; sIL-1RI
uniprot entry name :
IL1R1_HUMAN
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
18-336
sequence length :
319
sequence :
LEA DKCKEREEKI ILVSSANEID VRPCPLNPNE HKGTITWYKD DSKTPVSTEQ ASRIHQHKEK LWFVPAKVED SGHYYCVVRN SSYCLRIKIS AKFVENEPNL CYNAQAIFKQ KLPVAGDGGL VCPYMEFFKN ENNELPKLQW YKDCKPLLLD NIHFSGVKDR LIVMNVAEKH RGNYTCHASY TYLGKQYPIT RVIEFITLEE NKPTRPVIVS PANETMEVDL GSQIQLICNV TGQLSDIAYW KWNGSVIDED DPVLGEDYYS VENPANKRRS TLITVLNISE IESRFYKHPF TCFAKNTHGI DAAYIQLIYP VTNFQK
purity :
>90%
form :
Liquid containing glycerol; lyophilization may be available upon request.
storage stability :
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
other info1 :
Species: Homo sapiens (Human)
ncbi gi num :
4504659
ncbi acc num :
NP_000868.1
ncbi gb acc num :
NM_000877.3
uniprot acc num :
P14778
ncbi mol weight :
65,402 Da
ncbi pathways :
Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Apoptosis Pathway (83060); Apoptosis Pathway (470); Apoptosis Modulation And Signaling Pathway (198822); Cytokine Signaling In Immune System Pathway (366171); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); HTLV-I Infection Pathway (373901); HTLV-I Infection Pathway (373889)
ncbi summary :
This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. [provided by RefSeq, Dec 2013]
uniprot summary :
IL-1RA: Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Belongs to the interleukin-1 receptor family. Protein type: Receptor, cytokine; EC 2.7.11.25; Membrane protein, integral. Chromosomal Location of Human Ortholog: 2q12. Cellular Component: cell surface; membrane; integral to plasma membrane; plasma membrane; extracellular region. Molecular Function: interleukin-1, Type I, activating receptor activity; signal transducer activity; protein binding; transmembrane receptor activity; protease binding; platelet-derived growth factor receptor binding; interleukin-1 receptor activity. Biological Process: cell surface receptor linked signal transduction; regulation of inflammatory response; immune response
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price1 :
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more info or order :
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company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
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