protein

Recombinant human 60S ribosomal protein L5

MBS717274

0.05 mg

195 USD

Recombinant Protein

Recombinant human 60S ribosomal protein L5

60S ribosomal protein L5

Recombinant human 60S ribosomal protein L5 protein

Homo sapiens ribosomal protein L5 (RPL5), mRNA; 60S ribosomal protein L5; 60S ribosomal protein L5; ribosomal protein L5

RPL5; RPL5; L5; DBA6; MSTP030

RL5_HUMAN

E Coli

GFVKVVKNKAYFKRYQVKFRRRREGKTDYYARKRLVIQD
KNKYNTPKYRMIVRVTNRDIICQIAYARIEGDMIVCAAY
AHELPKYGVKVGLTNYAAAYCTGLLLARRLLNRFGMDKI
YEGQVEVTGDEYNVESIDGQPGAFTCYLDAGLARTTTGN
KVFGALKGAVDGGLSIPHSTKRFPGYDSESKEFNAEVHR
KHIMGQNVADYMRYLMEEDEDAYKKQFSQYIKNSVTPDM
MEEMYKKAHAAIRENPVYEKKPKKEVKKKRWNRPKMSLA
QKKDRVAQKKASFLRAQERAAES

0.95

Store at -20 degree C. For extended storage, conserve at -20 or -80 degree C.

Tag Information: GST-tagged

Storage Buffer: PBS pH 7.4, 50% glycerol

Required for rRNA maturation and formation of the 60S ribosomal subunits. This protein binds 5S RNA.

[1] "Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs.

71772259

NP_000960.2

NM_000969.3

P46777

60 KD

Cap-dependent Translation Initiation Pathway 105967!!Cytoplasmic Ribosomal Proteins Pathway 198853!!Disease Pathway 530764!!Eukaryotic Translation Elongation Pathway 105976!!Eukaryotic Translation Initiation Pathway 105966!!Eukaryotic Translation Termination Pathway 105978!!Formation Of A Pool Of Free 40S Subunits Pathway 105968!!GTP Hydrolysis And Joining Of The 60S Ribosomal Subunit Pathway 105973!!Gene Expression Pathway 105937!!Influenza Infection Pathway 106067

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L18P family of ribosomal proteins. It is located in the cytoplasm. The protein binds 5S rRNA to form a stable complex called the 5S ribonucleoprotein particle (RNP), which is necessary for the transport of nonribosome-associated cytoplasmic 5S rRNA to the nucleolus for assembly into ribosomes. The protein interacts specifically with the beta subunit of casein kinase II. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. This gene is co-transcribed with the small nucleolar RNA gene U21, which is located in its fifth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Function: Required for rRNA maturation and formation of the 60S ribosomal subunits. This protein binds 5S RNA. Ref.11. Subcellular location: Cytoplasm. Nucleus nucleolus Ref.7. Involvement in disease: Defects in RPL5 are the cause of Diamond-Blackfan anemia type 6 (DBA6) [. MIM:612561]. DBA6 is a form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. Ref.11 Ref.14. Sequence similarities: Belongs to the ribosomal protein L18P family.

0.05 mg

195 USD