Recombinant Human Fructose-bisphosphate aldolase A | MyBioSource MBS717273 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Fructose-bisphosphate aldolase A

catalog :

MBS717273

quantity :

0.05 mg (E-Coli)

price :

190 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS717273

products type :

Recombinant Protein

products full name :

Recombinant Human Fructose-bisphosphate aldolase A

products short name :

Fructose-bisphosphate aldolase A

products name syn :

Lung cancer antigen NY-LU-1; Muscle-type aldolase

other names :

fructose-bisphosphate aldolase A isoform 1; Fructose-bisphosphate aldolase A; fructose-bisphosphate aldolase A; aldolase, fructose-bisphosphate A; Lung cancer antigen NY-LU-1; Muscle-type aldolase

products gene name :

ALDOA

other gene names :

ALDOA; ALDOA; ALDA; GSD12; HEL-S-87p; ALDA

uniprot entry name :

ALDOA_HUMAN

host :

E Coli

sequence positions :

2-364

sequence length :

364

sequence :

PYQYPALTPEQKKELSDIAHRIVAPGKGILAADESTGSI
AKRLQSIGTENTEENRRFYRQLLLTADDRVNPCIGGVIL
FHETLYQKADDGRPFPQVIKSKGGVVGIKVDKGVVPLAG
TNGETTTQGLDGLSERCAQYKKDGADFAKWRCVLKIGEH
TPSALAIMENANVLARYASICQQNGIVPIVEPEILPDGD
HDLKRCQYVTEKVLAAVYKALSDHHIYLEGTLLKPNMVT
PGHACTQKFSHEEIAMATVTA

purity :

Greater than 90% as determined by SDS-PAGE.

storage stability :

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.

products categories :

Metabolism

products description :

Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein.

products references :

Nucleotide sequence of a cDNA clone for human aldolase a messenger RNA in the liver.Sakakibara M., Mukai T., Hori K.Biochem. Biophys. Res. Commun. 131:413-420(1985)

ncbi gi num :

4557305

ncbi acc num :

NP_000025.1

ncbi gb acc num :

NM_000034.3

uniprot acc num :

P04075

ncbi mol weight :

66.7kD

ncbi pathways :

Biosynthesis Of Amino Acids Pathway (790012); Biosynthesis Of Amino Acids Pathway (795174); Carbon Metabolism Pathway (814926); Carbon Metabolism Pathway (817567); Fructose And Mannose Metabolism Pathway (82930); Fructose And Mannose Metabolism Pathway (291); Gluconeogenesis Pathway (1269961); Gluconeogenesis, Oxaloacetate = Fructose-6P Pathway (413342); Gluconeogenesis, Oxaloacetate = Fructose-6P Pathway (468196); Glucose Metabolism Pathway (1269959)

ncbi summary :

The protein encoded by this gene, Aldolase A (fructose-bisphosphate aldolase), is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Aldolase A is found in the developing embryo and is produced in even greater amounts in adult muscle. Aldolase A expression is repressed in adult liver, kidney and intestine and similar to aldolase C levels in brain and other nervous tissue. Aldolase A deficiency has been associated with myopathy and hemolytic anemia. Alternative splicing and alternative promoter usage results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 3 and 10. [provided by RefSeq, Aug 2011]

uniprot summary :

ALDOA: a glycolytic enzyme that catalyzes D-fructose 1,6-bisphosphate - glycerone phosphate + D-glyceraldehyde 3-phosphate. Three forms of aldolase are found in vertebrates - aldolase A in muscle, aldolase B in liver and aldolase C in brain. Protein type: Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - pentose phosphate pathway; Mitochondrial; Lyase; EC 4.1.2.13. Chromosomal Location of Human Ortholog: 16p11.2. Cellular Component: actin cytoskeleton; cytosol; extracellular region; extracellular space; I band; M band; membrane; nucleus. Molecular Function: actin binding; cytoskeletal protein binding; fructose-bisphosphate aldolase activity; identical protein binding; protein binding; tubulin binding. Biological Process: actin filament organization; ATP biosynthetic process; blood coagulation; carbohydrate metabolic process; fructose 1,6-bisphosphate metabolic process; fructose metabolic process; gluconeogenesis; glucose metabolic process; glycolysis; muscle maintenance; platelet activation; platelet degranulation; protein homotetramerization; regulation of cell shape; striated muscle contraction. Disease: Glycogen Storage Disease Xii

size1 :

0.05 mg (E-Coli)

price1 :

190 USD

size2 :

0.2 mg (E-Coli)

price2 :

460

size3 :

0.5 mg (E-Coli)

price3 :

750

size4 :

1 mg (E-Coli)

price4 :

1180

more info or order :

MyBioSource product webpage