catalog number :
MBS717226
products type :
Recombinant Protein
products full name :
Recombinant human Rab GDP dissociation inhibitor beta protein
products short name :
Rab GDP dissociation inhibitor beta protein
products name syn :
Recombinant human Rab GDP dissociation inhibitor beta protein
other names :
Homo sapiens GDP dissociation inhibitor 2 (GDI2), transcript variant 1, mRNA; Rab GDP dissociation inhibitor beta; rab GDP dissociation inhibitor beta; GDI-2; rab GDI beta; rab GDP-dissociation inhibitor, beta; guanosine diphosphate dissociation inhibitor 2; GDP dissociation inhibitor 2; Guanosine diphosphate dissociation inhibitor 2
other gene names :
GDI2; GDI2; RABGDIB; RABGDIB; Rab GDI beta; GDI-2
uniprot entry name :
GDIB_HUMAN
sequence :
MNEEYDVIVLGTGLTECILSGIMSVNGKKVLHMDRNPYY
GGESASITPLEDLYKRFKIPGSPPESMGRGRDWNVDLIP
KFLMANGQLVKMLLYTEVTRYLDFKVTEGSFVYKGGKIY
KVPSTEAEALASSLMGLFEKRRFRKFLVYVANFDEKDPR
TFEGIDPKKTTMRDVYKKFDLGQDVIDFTGHALALYRTD
DYLDQPCYETINRIKLYSESLARYGKSPYLYPLYGLGEL
PQGFARLSAIYGGTYMLNKPIEEIIVQNGKVIGVKSEGE
IARCKQLICDPSYVKDRVEKVGQVIRVICILSHPIKNTN
DANSCQIIIPQNQVNRKSDIYVCMISFAHNVAAQGKYIA
IVSTTVETKEPEKEIRPALELLEPIEQKFVSISDLLVPK
DLGTESQIFISRTYDATTHFETTCDDIKNIYKRMTGSEF
DFEEMKRKKNDI
storage stability :
Store at -20 degree C. For extended storage, conserve at -20 or -80 degree C.
other info1 :
Tag Information: GST tagged
other info2 :
Storage Buffer: PBS pH 7.4, 50% glycerol
products description :
Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.
products references :
[1] Asada M., Kaibuchi K., Takai Y.
ncbi acc num :
NP_001485.2
ncbi gb acc num :
NM_001494.3
ncbi pathways :
Rho GTPase Cycle Pathway 106503!!Signal Transduction Pathway 477114!!Signaling By Rho GTPases Pathway 106502
ncbi summary :
GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI2 is ubiquitously expressed. The GDI2 gene contains many repetitive elements indicating that it may be prone to inversion/deletion rearrangements. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
uniprot summary :
Function: Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Subunit structure: Interacts with RHOH. Ref.9. Subcellular location: Cytoplasm . By similarity. Membrane; Peripheral membrane protein . By similarity. Tissue specificity: Ubiquitous. Ref.8. Sequence similarities: Belongs to the Rab GDI family.