protein

Recombinant human 40S ribosomal protein S24

MBS717151

0.05 mg

195 USD

Recombinant Protein

Recombinant human 40S ribosomal protein S24

40S ribosomal protein S24

Recombinant human 40S ribosomal protein S24 protein

Homo sapiens ribosomal protein S24 (RPS24), transcript variant c, mRNA; 40S ribosomal protein S24; 40S ribosomal protein S24; ribosomal protein S24

RPS24; RPS24; S24; DBA3

RS24_HUMAN

E Coli

NDTVTIRTRKFMTNRLLQRKQMVIDVLHPGKATVPKTEI
REKLAKMYKTTPDVIFVFGFRTHFGGGKTTGFGMIYDSL
DYAKKNEPKHRLARHGLYEKKKTSRKQRKERKNRMKKVR
GTAKANVGAGKKPKE

0.9

Store at -20 degree C. For extended storage, conserve at -20 or -80 degree C.

Tag Information: GST tagged

Storage Buffer: PBS pH 7.4, 50% glycerol

Required for processing of pre-rRNA and maturation of 40S ribosomal subunits.

[1] "A cDNA encoding human ribosomal protein S24.

214829180

NP_001017.1

NM_001026.4

P62847

42 KD

Activation Of The MRNA Upon Binding Of The Cap-binding Complex And EIFs, And Subsequent Binding To 43S Pathway 105970!!Cap-dependent Translation Initiation Pathway 105967!!Cytoplasmic Ribosomal Proteins Pathway 198853!!Disease Pathway 530764!!Eukaryotic Translation Elongation Pathway 105976!!Eukaryotic Translation Initiation Pathway 105966!!Eukaryotic Translation Termination Pathway 105978!!Formation Of A Pool Of Free 40S Subunits Pathway 105968!!Formation Of The Ternary Complex, And Subsequently, The 43S Complex Pathway 105969!!GTP Hydrolysis And Joining Of The 60S Ribosomal Subunit Pathway 105973

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S24E family of ribosomal proteins. It is located in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Mutations in this gene result in Diamond-Blackfan anemia. [provided by RefSeq, Nov 2008]

Function: Required for processing of pre-rRNA and maturation of 40S ribosomal subunits. Ref.12. Tissue specificity: Mature tissues, such as adult brain, skeletal muscle, heart, and kidney, express low levels, whereas tissues and organs with significant populations of proliferating cells, such as fetal brain, placenta, bone marrow, and various glandular organs, contain significantly higher levels. Ref.10. Involvement in disease: Defects in RPS24 are the cause of Diamond-Blackfan anemia type 3 (DBA3) [. MIM:610629]. DBA3 is a form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. Ref.10. Sequence similarities: Belongs to the ribosomal protein S24e family.

0.05 mg

195 USD