catalog number :
MBS717089
products type :
Recombinant Protein
products full name :
Recombinant Human Actin-related protein 2/3 complex subunit 2
products short name :
Actin-related protein 2/3 complex subunit 2
products name syn :
Arp2/3 complex 34 kDa subunit; p34-AR; C
other names :
actin-related protein 2/3 complex subunit 2; Actin-related protein 2/3 complex subunit 2; actin-related protein 2/3 complex subunit 2; actin related protein 2/3 complex subunit 2; Arp2/3 complex 34 kDa subunit; p34-ARC
products gene name :
ARPC2
products gene name syn :
ARC34; PRO2446
other gene names :
ARPC2; ARPC2; ARC34; PRO2446; p34-Arc; PNAS-139; ARC34; p34-ARC
uniprot entry name :
ARPC2_HUMAN
sequence positions :
1-250
sequence :
MILLEVNNRIIEETLALKFENAAAGNKPEAVEVTFADFD
GVLYHISNPNGDKTKVMVSISLKFYKELQAHGADELLKR
VYGSFLVNPESGYNVSLLYDLENLPASKDSIVHQAGMLK
RNCFASVFEKYFQFQEEGKEGENRAVIHYRDDETMYVES
KKDRVTVVFSTVFKDDDDVVIGKVFMQEFKEGRRASHTA
PQVLFSHREPPLELKDTDAAVGDNIGYITFVLFPRHTNA
SARDNTINLIHTFRDY
purity :
Greater than 90% as determined by SDS-PAGE.
storage stability :
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
products categories :
Signal Transduction
products description :
Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Ses to contact the mother actin filament.
products references :
The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly.Welch M.D., Depace A.H., Verma S., Iwamatsu A., Mitchison T.J.J. Cell Biol. 138:375-384(1997)
ncbi acc num :
NP_005722.1
ncbi gb acc num :
NM_005731.3
ncbi pathways :
Axon Guidance Pathway (1270303); B Cell Receptor Signaling Pathway (198909); Bacterial Invasion Of Epithelial Cells Pathway (149807); Bacterial Invasion Of Epithelial Cells Pathway (148661); CDC42 Signaling Events Pathway (137994); Developmental Biology Pathway (1270302); EPH-Ephrin Signaling Pathway (1270330); EPHB-mediated Forward Signaling Pathway (1270332); Endocytosis Pathway (102279); Endocytosis Pathway (102181)
ncbi summary :
This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p34 subunit, has yet to be determined. Two alternatively spliced variants have been characterized to date. Additional alternatively spliced variants have been described but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
uniprot summary :
ARPC2: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament. Belongs to the ARPC2 family. Protein type: Motility/polarity/chemotaxis; Cytoskeletal; Actin-binding. Chromosomal Location of Human Ortholog: 2q36.1. Cellular Component: actin cytoskeleton; Arp2/3 protein complex; cytoplasm; cytosol; endosome; focal adhesion; Golgi apparatus; leading edge; neuron projection; synapse. Molecular Function: actin filament binding; protein binding; structural constituent of cytoskeleton. Biological Process: axon guidance; cell motility; ephrin receptor signaling pathway; innate immune response; small GTPase mediated signal transduction