product summary
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company name :
MyBioSource
product type :
protein
product name :
Recombinant Human Eukaryotic initiation factor 4A-II protein
catalog :
MBS717088
quantity :
0.05 mg (E-Coli)
price :
190 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS717088
products type :
Recombinant Protein
products full name :
Recombinant Human Eukaryotic initiation factor 4A-II protein
products short name :
Eukaryotic initiation factor 4A-II
products name syn :
ATP-dependent RNA helicase eIF4A-2
other names :
eukaryotic initiation factor 4A-II; Eukaryotic initiation factor 4A-II; eukaryotic initiation factor 4A-II; eukaryotic translation initiation factor 4A2; ATP-dependent RNA helicase eIF4A-2
products gene name :
EIF4A2
products gene name syn :
DDX2B; EIF4F
other gene names :
EIF4A2; EIF4A2; DDX2B; EIF4A; EIF4F; BM-010; eIF4A-II; eIF-4A-II; DDX2B; EIF4F; eIF-4A-II; eIF4A-II
uniprot entry name :
IF4A2_HUMAN
host :
E Coli
sequence positions :
1-407
sequence length :
407
sequence :
MSGGSADYNREHGGPEGMDPDGVIESNWNEIVDNFDDMN
LKESLLRGIYAYGFEKPSAIQQRAIIPCIKGYDVIAQAQ
SGTGKTATFAISILQQLEIEFKETQALVLAPTRELAQQI
QKVILALGDYMGATCHACIGGTNVRNEMQKLQAEAPHIV
VGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSRGFKD
QIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIR
ILVKKEELTLEGIKQFYINVE
purity :
Greater than 90% as determined by SDS-PAGE.
storage stability :
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
products categories :
Immunology
products description :
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
products references :
Isolation and mapping of the human EIF4A2 gene homologous to the murine protein synthesis initiation factor 4A-II gene Eif4a2.Sudo K., Takahashi E., Nakamura Y.Cytogenet. Cell Genet. 71:385-388(1995)
ncbi gi num :
83700235
ncbi acc num :
NP_001958.2
ncbi gb acc num :
NM_001967.3
uniprot acc num :
Q14240
ncbi mol weight :
73.8kD
ncbi pathways :
Activation Of The MRNA Upon Binding Of The Cap-binding Complex And EIFs, And Subsequent Binding To 43S Pathway (1268683); Antiviral Mechanism By IFN-stimulated Genes Pathway (1269316); Cap-dependent Translation Initiation Pathway (1268680); Cytokine Signaling In Immune System Pathway (1269310); Deadenylation Of MRNA Pathway (1269713); Deadenylation-dependent MRNA Decay Pathway (1269712); Eukaryotic Translation Initiation Pathway (1268679); GTP Hydrolysis And Joining Of The 60S Ribosomal Subunit Pathway (1268686); Gene Expression Pathway (1269649); ISG15 Antiviral Mechanism Pathway (1269317)
uniprot summary :
EIF4A2: ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon. Belongs to the DEAD box helicase family. eIF4A subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: EC 3.6.4.13; RNA-binding; Helicase; Translation; Translation initiation. Chromosomal Location of Human Ortholog: 3q28. Cellular Component: cytosol; eukaryotic translation initiation factor 4F complex; perinuclear region of cytoplasm. Molecular Function: ATP binding; ATP-dependent RNA helicase activity; ATPase activity; helicase activity; protein binding; translation initiation factor activity. Biological Process: cellular protein metabolic process; cytokine and chemokine mediated signaling pathway; gene expression; mRNA catabolic process, deadenylation-dependent decay; poly(A) tail shortening; regulation of translational initiation; RNA secondary structure unwinding; translation; translational initiation; viral reproduction
size1 :
0.05 mg (E-Coli)
price1 :
190 USD
size2 :
0.2 mg (E-Coli)
price2 :
460
size3 :
0.5 mg (E-Coli)
price3 :
750
size4 :
1 mg (E-Coli)
price4 :
1180
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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