product summary
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company name :
MyBioSource
product type :
protein
product name :
Recombinant human D-3-phosphoglycerate dehydrogenase
catalog :
MBS717072
quantity :
0.05 mg
price :
195 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS717072
products type :
Recombinant Protein
products full name :
Recombinant human D-3-phosphoglycerate dehydrogenase
products short name :
D-3-phosphoglycerate dehydrogenase
other names :
Homo sapiens phosphoglycerate dehydrogenase (PHGDH), mRNA; D-3-phosphoglycerate dehydrogenase; D-3-phosphoglycerate dehydrogenase; OTTHUMP00000013926; OTTHUMP00000013927; phosphoglycerate dehydrogenase
other gene names :
PHGDH; PHGDH; PDG; PGD; PGAD; PGDH; SERA; 3PGDH; 3-PGDH; MGC3017; PGDH3
uniprot entry name :
SERA_HUMAN
host :
E Coli
sequence :
AFANLRKVLISDSLDPCCRKILQDGGLQVVEKQNLSKEE
LIAELQDCEGLIVRSATKVTADVINAAEKLQVVGRAGTG
VDNVDLEAATRKGILVMNTPNGNSLSAAELTCGMIMCLA
RQIPQATASMKDGKWERKKFMGTELNGKTLGILGLGRIG
REVATRMQSFGMKTIGYDPIISPEVSASFGVQQLPLEEI
WPLCDFITVHTPLLPSTTGLLNDNTFAQCKKGVRVVNCA
RGGIVDEGALLRALQSGQCAGAALDVFTEEPPRDRALVD
HENVISCPHLGASTKEAQSRCGEEIAVQFVDMVKGKSLT
GVVNAQALTSAFSPHTKPWIGLAEALGTLMRAWAGSPKG
TIQVITQGTSLKNAGNCLSPAVIVGLLKEASKQADVNLV
NAKLLVKEAGLNVTTSHSPAAPGEQGFGECLLAVALAGA
PYQAVGLVQGTTPVLQGLNGAVFRPEVPLRRDLPLLLFR
TQTSDPAMLPTMIGLLAEAGVRLLSYQTSLVSDGETWHV
MGISSLLPSLEAWKQHVTEAFQFHF
purity :
>90%(SDS-PAGE)
storage stability :
Store at -20 degree C. For extended storage, conserve at -20 or -80 degree C. Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
products description :
3-phospho-D-glycerate + NAD+ = 3-phosphonooxypyruvate + NADH.
ncbi gi num :
217272837
ncbi acc num :
NP_006614.2
ncbi gb acc num :
NM_006623
uniprot acc num :
O43175
ncbi mol weight :
63kD
ncbi pathways :
Glycine, Serine And Threonine Metabolism Pathway (82949); Glycine, Serine And Threonine Metabolism Pathway (313); Metabolic Pathways (132956)
ncbi summary :
3-Phosphoglycerate dehydrogenase (PHGDH; EC 1.1.1.95) catalyzes the transition of 3-phosphoglycerate into 3-phosphohydroxypyruvate, which is the first and rate-limiting step in the phosphorylated pathway of serine biosynthesis, using NAD+/NADH as a cofactor.[supplied by OMIM, Apr 2004]
uniprot summary :
Catalytic activity: 3-phospho-D-glycerate + NAD+ = 3-phosphonooxypyruvate + NADH. Ref.102-hydroxyglutarate + NAD+ = 2-oxoglutarate + NADH. Ref.10Pathway: Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.Subunit structure: Homotetramer By similarity.Induction: Induced by 17-beta-estradiol (estrogenic ligand) and 4-hydroxytamoxifen (agonist/antagonist ligand). Positively regulated by the transcription factors SP1 and NF-Y. Ref.11 Ref.12Involvement in disease: Defects in PHGDH are the cause of phosphoglycerate dehydrogenase deficiency (PHGDH deficiency) [MIM:601815]. It is characterized by congenital microcephaly, psychomotor retardation, and seizures.Sequence similarities: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.Biophysicochemical propertiesKinetic parameters:KM=21.6 uM for 3-phosphohydroxypyruvate Ref.16Vmax=35 nmol/min/mg enzyme with 3-phosphohydroxypyruvate as substrate (in patient-derived fibroblasts)Vmax=168 nmol/min/mg enzyme with 3-phosphohydroxypyruvate as substrate (in 3-PGDH overexpressed cells)
size1 :
0.05 mg
price1 :
195 USD
size2 :
0.2 mg
price2 :
465
size3 :
0.5 mg
price3 :
815
size4 :
1 mg
price4 :
1290
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
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