protein

Human IgM

MBS717031

1 mg

245 USD

Native Protein

Human IgM

IgM

IgM, partial

Purified from pooled normal human serum

>95% (SDS-PAGE)

Liquid

Aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze / thaw cycles

ELISA (EIA), Western Blot (WB)

Peptide: Full length native human IgM

Storage Buffer: 50mM Tris,200mM Nacl,PH8.0

IgM normally constitutes about 10% of serum immunoglobulins. IgM antibody is prominent in early immune responses to most antigens and predominates in certain antibody responses such as ’natural’ blood group antibodies. IgM (with IgD) is the major immunoglobulin expressed on the surface of B cells. The gene for the mu constant region contains four domains separated by short intervening sequences. Class specific anti immunoglobulin antibodies are useful for: The characterization of malignant B cell proliferations. All but acute lymphocytic leukemias share either surface or intra cytoplasmic Ig with an isotypic restriction, which suggest the monoclonal nature of the cell population. Most of the chronic lymphocytic leukemias, non Hodgkin lymphomas and Burkitt’s lymphoma bear surface IgM, whereas plasmocytes from Waldenstr .

1020017

AAC41922.1

1 mg

245 USD