protein

Human Immunoglobulin G3

MBS717008

10 mg

345 USD

Native Protein

Human Immunoglobulin G3

Immunoglobulin G3

Purified from pooled normal human serum

>95%(SDS-PAGE)

Liquid

Aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze / thaw cycles

ELISA (EIA), Western Blot (WB)

Peptide: Full length native human IgG3

Storage Buffer: PBS,50% glycerol

IgG is a monomeric immunoglobulin, built of two heavy chains gamma and two light chains. Each molecule has two antigen binding sites. This is the most abundant immunoglobulin and is approximately equally distributed in blood and in tissue liquids, constituting 75% of serum immunoglobulins.It can bind to many kinds of pathogens, for example viruses, bacteria, and fungi, and protects the body against them by complement activation (classic pathway), opsonization for phagocytosis and neutralisation of their toxins. There are 4 subclasses: IgG1 (66%), IgG2 (23%), IgG3 (7%) and IgG4 (4%). IgG3 differs from the other subclasses by its unique extended hinge region (about four times as long as the IgG1 hinge), containing 62 amino acids (including 21 prolines and 11 cysteines), forming an inflexible poly-proline double helix. In IgG3 the Fab fragments are relatively far away from the Fc fragment, giving the molecule a greater flexibility. The elongated hinge in IgG3 is also responsible for its higher molecular weight compared to the other subclasses.

10 mg

345 USD