catalog number :
MBS716944
products full name :
Rabbit anti-human v-crk sarcoma virus CT10 oncogene homolog (avian) polyclonal Antibody
products short name :
v-crk sarcoma virus CT10 oncogene homolog
products name syn :
v-crk sarcoma virus CT10 oncogene homolog (avian); CRK; CRKII
other names :
V-crk sarcoma virus CT10 oncogene homolog (avian); Adapter molecule crk; adapter molecule crk; proto-oncogene c-Crk; v-crk avian sarcoma virus CT10 oncogene homolog; Proto-oncogene c-Crk; p38
other gene names :
CRK; CRK; p38; CRKII
uniprot entry name :
CRK_HUMAN
reactivity :
Human, Mouse, Rat
purity :
Antigen Affinity Purified
tested application :
ELISA (EIA), Western Blot (WB)
other info1 :
Immunogen: Human CRK
other info2 :
Storage Buffer: PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
ncbi acc num :
AAH01718.1
ncbi mol weight :
22,906 Da
ncbi pathways :
ARMS-mediated Activation Pathway 106466!!Angiopoietin Receptor Tie2-mediated Signaling Pathway 137917!!B Cell Receptor Signaling Pathway 198909!!Bacterial Invasion Of Epithelial Cells Pathway 149807!!Bacterial Invasion Of Epithelial Cells Pathway 148661!!CXCR4-mediated Signaling Events Pathway 137910!!Chemokine Signaling Pathway 99051!!Chemokine Signaling Pathway 96864!!Chronic Myeloid Leukemia Pathway 83116!!Chronic Myeloid Leukemia Pathway 528
ncbi summary :
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]