Rabbit anti-human ryanodine receptor 2 (cardiac) polyclonal Antibody | MyBioSource MBS716680 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit anti-human ryanodine receptor 2 (cardiac) polyclonal Antibody

catalog :

MBS716680

quantity :

0.05 mL

price :

375 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS716680

products type :

Antibody

products full name :

Rabbit anti-human ryanodine receptor 2 (cardiac) polyclonal Antibody

products short name :

ryanodine receptor 2

products name syn :

ryanodine receptor 2 (cardiac); RYR2; ARVC2; ARVD2; VTSIP

other names :

ryanodine receptor 2; Ryanodine receptor 2; ryanodine receptor 2; type 2 ryanodine receptor; islet-type ryanodine receptor; kidney-type ryanodine receptor; cardiac-type ryanodine receptor; cardiac muscle ryanodine receptor-calcium release channel; ryanodine receptor 2 (cardiac); Cardiac muscle ryanodine receptor; Cardiac muscle ryanodine receptor-calcium release channel; Type 2 ryanodine receptor

other gene names :

RYR2; RYR2; RyR; ARVC2; ARVD2; RYR-2; VTSIP; RYR-2; RyR2; hRYR-2

uniprot entry name :

RYR2_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

4967

purity :

Antigen Affinity Purified

tested application :

ELISA (EIA), Western Blot (WB)

other info1 :

Immunogen: Human RYR2

other info2 :

Storage Buffer: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.

ncbi gi num :

112799847

ncbi acc num :

NP_001026.2

ncbi gb acc num :

NM_001035.2

ncbi mol weight :

565,411 Da

ncbi pathways :

Adrenergic Signaling In Cardiomyocytes Pathway (908257); Adrenergic Signaling In Cardiomyocytes Pathway (909696); Arrhythmogenic Right Ventricular Cardiomyopathy Pathway (672454); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (117293); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (116129); Calcium Regulation In The Cardiac Cell Pathway (198906); Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Cardiac Muscle Contraction Pathway (93344); Cardiac Muscle Contraction Pathway (93992)

ncbi summary :

This gene encodes a ryanodine receptor found in cardiac muscle sarcoplasmic reticulum. The encoded protein is one of the components of a calcium channel, composed of a tetramer of the ryanodine receptor proteins and a tetramer of FK506 binding protein 1B proteins, that supplies calcium to cardiac muscle. Mutations in this gene are associated with stress-induced polymorphic ventricular tachycardia and arrhythmogenic right ventricular dysplasia. [provided by RefSeq, Jul 2008]

uniprot summary :

RYR2: ryanodine receptor calcium release channel. Regulates communication between transverse-tubules and sarcoplasmic reticulum. Contraction of cardiac muscle is triggered by release of calcium ions from SR following depolarization of T-tubules. Phosphorylation by PKA dissociates FKBP12.6 from RYR2. Two splice isoforms have been described. Protein type: Membrane protein, multi-pass; Transporter, ion channel; Membrane protein, integral; Channel, ligand-gated; Transporter. Chromosomal Location of Human Ortholog: 1q43. Cellular Component: sarcoplasmic reticulum membrane; protein complex; smooth endoplasmic reticulum; sarcoplasmic reticulum; membrane; plasma membrane; Z disc. Molecular Function: calcium-induced calcium release activity; calmodulin binding; identical protein binding; protein binding; enzyme binding; protein self-association; calcium channel activity; calcium-release channel activity; calcium ion binding; intracellular ligand-gated calcium channel activity; ryanodine-sensitive calcium-release channel activity. Biological Process: positive regulation of sequestering of calcium ion; cytosolic calcium ion homeostasis; regulation of heart rate; calcium-mediated signaling; positive regulation of heart rate; response to redox state; Wnt receptor signaling pathway through beta-catenin; release of sequestered calcium ion by sarcoplasmic reticulum into cytosol; response to caffeine; BMP signaling pathway; cellular calcium ion homeostasis; calcium ion transport; release of sequestered calcium ion into cytosol; response to hypoxia; detection of calcium ion; transmembrane transport; cardiac muscle contraction. Disease: Ventricular Tachycardia, Catecholaminergic Polymorphic, 1, With Or Without Atrial Dysfunction And/or Dilated Cardiomyopathy; Arrhythmogenic Right Ventricular Dysplasia, Familial, 2

size1 :

0.05 mL

price1 :

375 USD

size2 :

0.15 mL

price2 :

715

more info or order :

MyBioSource product webpage