product summary
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company name :
MyBioSource
product type :
antibody
product name :
Rabbit anti-human prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) polyclonal Antibody
catalog :
MBS716487
quantity :
0.05 mL
price :
375 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, enzyme immunoassay
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS716487
products type :
Antibody
products full name :
Rabbit anti-human prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) polyclonal Antibody
products short name :
prostaglandin-endoperoxide synthase 1
products name syn :
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase); PTGS1; COX1; COX3; PCOX1; PGG/HS; PGHS-1; PGHS1; PHS1; PTGHS
other names :
prostaglandin-endoperoxide synthase 1; Prostaglandin G/H synthase 1; prostaglandin G/H synthase 1; PGH synthase 1; cyclooxygenase-1; prostaglandin H2 synthase 1; prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase); Cyclooxygenase-1; COX-1; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1; Prostaglandin-endoperoxide synthase 1
other gene names :
PTGS1; PTGS1; COX1; COX3; PHS1; PCOX1; PES-1; PGHS1; PTGHS; PGG/HS; PGHS-1; COX1; COX-1; PGH synthase 1; PGHS-1; PHS 1
uniprot entry name :
PGH1_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human, Mouse, Rat; Other species are not tested. Please decide the specificity by homology.
sequence length :
599
purity :
Antigen Affinity Purified
form :
Liquid
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
app notes :
ELISA: Use at an assay dependent dilution. WB: 1:200-1:2000 . IHC: 1:20-1:200 (Recommender dilutions) . Positive WB detected in : Mouse lung tissue, mouse kidney tissue . Positive IHC detected in : Human stomach tissue
other info1 :
Conjugate: Non-conjugated . Immunogen: Human PTGS1
other info2 :
Storage Buffer: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
products description :
May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells.
ncbi gi num :
17017287
ncbi acc num :
AAL33601.1
ncbi mol weight :
72,010 Da
ncbi pathways :
Arachidonic Acid Metabolism Pathway (82991); Arachidonic Acid Metabolism Pathway (685553); Arachidonic Acid Metabolism Pathway (366); Biological Oxidations Pathway (105698); C20 Prostanoid Biosynthesis Pathway (908107); COX Reactions Pathway (105711); Eicosanoid Synthesis Pathway (198888); Metabolic Pathways (132956); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976)
ncbi summary :
This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
uniprot summary :
COX-1: May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells. Homodimer. Belongs to the prostaglandin G/H synthase family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Lipid Metabolism - arachidonic acid; EC 1.14.99.1; Oxidoreductase. Chromosomal Location of Human Ortholog: 9q32-q33.3. Cellular Component: endoplasmic reticulum membrane; photoreceptor outer segment; intracellular membrane-bound organelle; cytoplasm; nucleus. Molecular Function: prostaglandin-endoperoxide synthase activity; peroxidase activity; dioxygenase activity; metal ion binding; heme binding. Biological Process: xenobiotic metabolic process; regulation of blood pressure; cyclooxygenase pathway; arachidonic acid metabolic process; lipid metabolic process; response to oxidative stress; prostaglandin biosynthetic process; inflammatory response; regulation of cell proliferation
size1 :
0.05 mL
price1 :
375 USD
size2 :
0.15 mL
price2 :
715
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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