catalog number :
MBS716277
products full name :
Rabbit anti-human cholecystokinin polyclonal Antibody
products short name :
cholecystokinin
products name syn :
cholecystokinin; CCK; MGC117187
other names :
cholecystokinin; Cholecystokinin; cholecystokinin; prepro-cholecystokinin; cholecystokinin triacontatriapeptide; cholecystokinin; (1-49)-CCK58
other gene names :
CCK; CCK; CCK; CCK58; CCK39; CCK33; CCK25; CCK18; CCK12; CCK8; CCK7; CCK5
uniprot entry name :
CCKN_HUMAN
reactivity :
Human, Mouse, Rat
purity :
Antigen Affinity Purified
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
other info1 :
Immunogen: Human CCK
other info2 :
Storage Buffer: PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
ncbi acc num :
AAA53094.1
ncbi mol weight :
12,669 Da
ncbi pathways :
Class A/1 (Rhodopsin-like Receptors) Pathway (106357); G Alpha (q) Signalling Events Pathway (106043); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); Gastrin-CREB Signalling Pathway Via PKC And MAPK (645295); Peptide Ligand-binding Receptors Pathway (106358); Signal Transduction Pathway (477114); Signaling By GPCR Pathway (106356)
ncbi summary :
Cholecystokinin is a brain/gut peptide. In the gut, it induces the release of pancreatic enzymes and the contraction of the gallbladder. In the brain, its physiologic role is unclear. The cholecystokinin pro-hormone is processed by endo- and exo-proteolytic cleavages. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010]
uniprot summary :
CCK: This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion. Belongs to the gastrin/cholecystokinin family. Protein type: Secreted; Secreted, signal peptide; Hormone; Cell development/differentiation. Chromosomal Location of Human Ortholog: 3p22.1. Cellular Component: axon hillock; extracellular space; axon; dendrite; extracellular region; terminal button; perikaryon. Molecular Function: neuropeptide hormone activity; protein binding; hormone activity. Biological Process: caspase activation; positive regulation of protein oligomerization; positive regulation of peptidyl-tyrosine phosphorylation; release of cytochrome c from mitochondria; behavioral fear response; axonogenesis; positive regulation of mitochondrial depolarization; eating behavior; positive regulation of cell proliferation; protein kinase C activation; neuron migration; regulation of sensory perception of pain; signal transduction; negative regulation of appetite