product summary
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company name :
MyBioSource
product type :
antibody
product name :
Rabbit anti-human transcription factor EB polyclonal Antibody
catalog :
MBS716265
quantity :
0.05 mL
price :
375 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunocytochemistry, enzyme immunoassay
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS716265
products type :
Antibody
products full name :
Rabbit anti-human transcription factor EB polyclonal Antibody
products short name :
transcription factor EB
products name syn :
transcription factor EB; TFEB; AlphaTFEB; TCFEB; bHLHe35
other names :
transcription factor EB; Transcription factor EB; Class E basic helix-loop-helix protein 35; bHLHe35
other gene names :
TFEB; BHLHE35; bHLHe35
uniprot entry name :
TFEB_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human, Mouse, Rat
sequence length :
490
purity :
Antigen Affinity Purified
tested application :
ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)
other info1 :
Immunogen: Human TFEB
other info2 :
Storage Buffer: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
ncbi gi num :
44843657
ncbi acc num :
CAE77681.1
uniprot acc num :
P19484
ncbi mol weight :
43,803 Da
uniprot summary :
TFEB: Transcription factor that specifically recognizes and binds E-box sequences (3 -CANNTG-5 ). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T- cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5 -GTCACGTGAC-3 ) present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta. Homodimer and heterodimer; with TFE3 or MITF. Belongs to the MiT/TFE family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: DNA-binding. Chromosomal Location of Human Ortholog: 6p21. Cellular Component: cytoplasm; nucleus. Molecular Function: protein dimerization activity; transcription factor activity. Biological Process: embryonic placenta development; regulation of transcription, DNA-dependent; transcription, DNA-dependent; lysosome organization and biogenesis; autophagy; positive regulation of transcription from RNA polymerase II promoter; humoral immune response; positive regulation of autophagy
size1 :
0.05 mL
price1 :
375 USD
size2 :
0.15 mL
price2 :
715
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

"MyBioSource offers the best products at unbeatable prices."

Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.

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