catalog number :
MBS716069
products full name :
Rabbit anti-human v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) polyclonal Antibody
products short name :
v-erb-a erythroblastic leukemia viral oncogene homolog 4
products name syn :
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian); ERBB4; HER4; MGC138404; p180erbB4
other names :
V-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian); Receptor tyrosine-protein kinase erbB-4; receptor tyrosine-protein kinase erbB-4; proto-oncogene-like protein c-ErbB-4; tyrosine kinase-type cell surface receptor HER4; v-erb-a erythroblastic leukemia viral oncogene homolog 4; avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4; Proto-oncogene-like protein c-ErbB-4; Tyrosine kinase-type cell surface receptor HER4; p180erbB4Cleaved into the following chain:ERBB4 intracellular domain; 4ICD; E4ICDAlternative name(s):s80HER4
other gene names :
ERBB4; ERBB4; HER4; ALS19; p180erbB4; HER4; 4ICD; E4ICD
uniprot entry name :
ERBB4_HUMAN
reactivity :
Human, Mouse, Rat
purity :
Antigen Affinity Purified
tested application :
ELISA (EIA), Western Blot (WB)
other info1 :
Immunogen: Human ERBB4
other info2 :
Storage Buffer: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
ncbi acc num :
AAI43742.1
ncbi mol weight :
143,968 Da
ncbi pathways :
Adaptive Immune System Pathway 366160!!Calcium Signaling Pathway 83050!!Calcium Signaling Pathway 459!!Constitutive PI3K/AKT Signaling In Cancer Pathway 685535!!DAP12 Interactions Pathway 685549!!DAP12 Signaling Pathway 685550!!Disease Pathway 530764!!Downregulation Of ERBB4 Signaling Pathway 530745!!Downstream Signal Transduction Pathway 106385!!Downstream Signaling Events Of B Cell Receptor (BCR) Pathway 576250
ncbi summary :
This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]