antibody

Rabbit anti- human Calmodulin polyclonal Antibody, FITC conjugated

MBS715920

0.05 mg

160 USD

polyclonal

rabbit

FITC

western blot, ELISA, enzyme immunoassay

Antibody

Rabbit anti- human Calmodulin polyclonal Antibody, FITC conjugated

Calmodulin

calmodulin isoform 1; Calmodulin; calmodulin; calmodulin 2 (phosphorylase kinase, delta)

CALM2; CALM1; caM; PHKD; CAMII; LQT15; PHKD2; CALM; CAM; CAM1; CaM

CALM_HUMAN

Polyclonal

IgG

Rabbit

Human

197

Caprylic Acid Ammonium Sulfate Precipitation Purified

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Western Blot (WB), ELISA (EIA)

Storage Buffer: PBS. Conjugate: FITC

Immunogen: Recombinant human Calmodulin protein

CALM2 is the second calmodulin gene. Although the CALM1,CALM2, and CALM3 calmodulin proteins are identical, at the nucleotide level they share only about 80% identity within their coding regions, and they contain no significant homology within their noncoding regions.

779176942

NP_001292553.1

NM_001305624.1

P62158

16,838 Da

ARMS-mediated Activation Pathway (1269471); Activation Of Ca-permeable Kainate Receptor Pathway (1268811); Activation Of CaMK IV Pathway (1268807); Activation Of Kainate Receptors Upon Glutamate Binding Pathway (1268808); Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway (1268798); Adaptive Immune System Pathway (1269171); Adrenergic Signaling In Cardiomyocytes Pathway (908257); Adrenergic Signaling In Cardiomyocytes Pathway (909696); Alcoholism Pathway (585563); Alcoholism Pathway (587116)

This gene is a member of the calmodulin gene family. There are three distinct calmodulin genes dispersed throughout the genome that encode the identical protein, but differ at the nucleotide level. Calmodulin is a calcium binding protein that plays a role in signaling pathways, cell cycle progression and proliferation. Several infants with severe forms of long-QT syndrome (LQTS) who displayed life-threatening ventricular arrhythmias together with delayed neurodevelopment and epilepsy were found to have mutations in either this gene or another member of the calmodulin gene family (PMID:23388215). Mutations in this gene have also been identified in patients with less severe forms of LQTS (PMID:24917665), while mutations in another calmodulin gene family member have been associated with catecholaminergic polymorphic ventricular tachycardia (CPVT)(PMID:23040497), a rare disorder thought to be the cause of a significant fraction of sudden cardiac deaths in young individuals. Pseudogenes of this gene are found on chromosomes 10, 13, and 17. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]

Calmodulin: a calcium-binding small regulatory protein that mediates the control of a large number of enzymes by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Has four functional calcium-binding domains. Phosphorylation and ubiquitination result in a decreased activity. Protein type: Calcium-binding. Chromosomal Location of Human Ortholog: 14q32.11. Cellular Component: centrosome; cytoplasm; cytosol; extracellular region; growth cone; nucleoplasm; nucleus; plasma membrane; sarcomere; spindle microtubule; spindle pole; vesicle. Molecular Function: adenylate cyclase binding; calcium ion binding; calcium-dependent protein binding; N-terminal myristoylation domain binding; nitric-oxide synthase binding; nitric-oxide synthase regulator activity; phosphoinositide 3-kinase binding; phospholipase binding; protein binding; protein domain specific binding; protein kinase binding; protein serine/threonine kinase activator activity; thioesterase binding; titin binding; type 3 metabotropic glutamate receptor binding. Biological Process: activation of MAPKK activity; adenylate cyclase activation; axon guidance; blood coagulation; carbohydrate metabolic process; detection of calcium ion; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; G-protein coupled receptor protein signaling pathway; glucose metabolic process; glycogen catabolic process; innate immune response; inositol phosphate metabolic process; insulin receptor signaling pathway; MAPKKK cascade; muscle contraction; nerve growth factor receptor signaling pathway; nitric oxide metabolic process; phospholipase C activation; phototransduction, visible light; platelet activation; platelet degranulation; positive regulation of cyclic nucleotide metabolic process; positive regulation of cyclic-nucleotide phosphodiesterase activity; positive regulation of nitric-oxide synthase activity; positive regulation of phosphoprotein phosphatase activity; positive regulation of protein amino acid autophosphorylation; positive regulation of protein amino acid dephosphorylation; Ras protein signal transduction; regulation of cytokinesis; regulation of heart rate; regulation of nitric-oxide synthase activity; regulation of rhodopsin mediated signaling; response to amphetamine; response to calcium ion; response to corticosterone stimulus; rhodopsin mediated signaling; signal transduction; small GTPase mediated signal transduction; stimulatory C-type lectin receptor signaling pathway; substantia nigra development; synaptic transmission; vascular endothelial growth factor receptor signaling pathway. Disease: Long Qt Syndrome 14; Ventricular Tachycardia, Catecholaminergic Polymorphic, 4

0.05 mg

160 USD

0.1 mg

235