catalog number :
MBS715668
products full name :
Rabbit anti-human D-3-phosphoglycerate dehydrogenase polyclonal Antibody; HRP conjugated
products short name :
D-3-phosphoglycerate dehydrogenase
products name syn :
3-PGDH PGDH3 PHGDH
other names :
D-3-phosphoglycerate dehydrogenase; D-3-phosphoglycerate dehydrogenase; D-3-phosphoglycerate dehydrogenase; epididymis secretory protein Li 113; phosphoglycerate dehydrogenase
other gene names :
PHGDH; PHGDH; NLS; PDG; PGD; NLS1; PGAD; PGDH; SERA; 3PGDH; 3-PGDH; PHGDHD; HEL-S-113; PGDH3; 3-PGDH
uniprot entry name :
SERA_HUMAN
purity :
Caprylic Acid Ammonium Sulfate Precipitation Purified
storage stability :
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
tested application :
Western Blot (WB), ELISA (EIA)
other info1 :
Immunogen: Recombinant human D-3-phosphoglycerate dehydrogenase protein. Relevance: PHGDH or 3-phosphoglycerate dehydrogenase is an enzyme belonging to the D-isomer specific 2-hydroxyacid dehydrogenase family. It catalysis the reaction 3-phosphoglycerate + NAD+ = 3-phosphonooxypyruvate + NADH during L-serine biosynthesis.
Defects in PHGDH are the cause of phosphoglycerate dehydrogenase deficiency (PHGDH deficiency). It is characterized by congenital microcephaly, psychomotor retardation and seizures.
other info2 :
Storage Buffer: Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
. Conjugate: HRP conjugated
ncbi acc num :
NP_006614.2
ncbi gb acc num :
NM_006623.3
ncbi mol weight :
56,651 Da
ncbi pathways :
Amino Acid Synthesis And Interconversion (transamination) Pathway 106173!!Biosynthesis Of Amino Acids Pathway 790012!!Biosynthesis Of Amino Acids Pathway 795174!!Carbon Metabolism Pathway 814926!!Carbon Metabolism Pathway 817567!!Glycine, Serine And Threonine Metabolism Pathway 82949!!Glycine, Serine And Threonine Metabolism Pathway 313!!Metabolic Pathways 132956!!Metabolism Pathway 477135!!Metabolism Of Amino Acids And Derivatives Pathway 106169
ncbi summary :
This gene encodes the enzyme which is involved in the early steps of L-serine synthesis in animal cells. L-serine is required for D-serine and other amino acid synthesis. The enzyme requires NAD/NADH as a cofactor and forms homotetramers for activity. Mutations in this gene have been found in a family with congenital microcephaly, psychomotor retardation and other symptoms. Multiple alternatively spliced transcript variants have been found, however the full-length nature of most are not known. [provided by RefSeq, Aug 2011]