antibody

Rabbit anti-human Beta-2-microglobulin polyclonal Antibody, Biotin conjugated

MBS715648

0.1 mg

235 USD

polyclonal

rabbit

biotin

western blot, ELISA, enzyme immunoassay

Antibody

Rabbit anti-human Beta-2-microglobulin polyclonal Antibody, Biotin conjugated

Beta-2-microglobulin

beta-2-microglobulin; Beta-2-microglobulin; beta-2-microglobulin; beta-2-microglobin; beta chain of MHC class I molecules; beta-2-microglobulin

B2M; B2M

B2MG_HUMAN

Polyclonal

IgG

Rabbit

Human

119

CA-AS

Liquid

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Western Blot (WB), ELISA (EIA)

Immunogen: Recombinant human Beta-2-microglobulin protein . Relevance: Beta 2 Microglobulin non-covalently associates with the 44 kDa alpha chain to form the HLA Class I antigen complex. Human beta 2 Microglobulin associated with HLA Class I antigens are expressed on many types of cells including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells. It is absent on erythrocytes.

Storage Buffer: PBS. Conjugate: Biotin

4757826

NP_004039.1

NM_004048.2

P61769

13,715 Da

Adaptive Immune System Pathway (366160); Amyloids Pathway (366238); Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway (366163); Antigen Processing And Presentation Pathway (83074); Antigen Processing And Presentation Pathway (485); Antigen Processing-Cross Presentation Pathway (477122); Class I MHC Mediated Antigen Processing Presentation Pathway (366161); Cytokine Signaling In Immune System Pathway (366171); DAP12 Interactions Pathway (685549); DAP12 Signaling Pathway (685550)

This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014]

B2M: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Heterodimer of an alpha chain and a beta chain. Beta-2- microglobulin is the beta-chain of major histocompatibility complex class I molecules. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. Belongs to the beta-2-microglobulin family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 15q21.1. Cellular Component: Golgi apparatus; extracellular space; focal adhesion; endoplasmic reticulum lumen; extracellular region; Golgi membrane; phagocytic vesicle membrane; membrane; early endosome membrane; cytoplasm; plasma membrane; MHC class I protein complex; external side of plasma membrane. Molecular Function: identical protein binding; protein binding. Biological Process: response to drug; regulation of immune response; viral reproduction; positive regulation of T cell mediated cytotoxicity; cytokine and chemokine mediated signaling pathway; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; T cell differentiation in the thymus; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; regulation of defense response to virus by virus; retinal homeostasis; iron ion homeostasis; antigen processing and presentation of peptide antigen via MHC class I; response to cadmium ion; response to molecule of bacterial origin; antigen processing and presentation of exogenous peptide antigen via MHC class I; innate immune response; protein refolding; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent. Disease: Hypoproteinemia, Hypercatabolic

0.1 mg

235 USD