Rabbit anti-human Gamma-aminobutyric acid receptor-associated protein polyclonal Antibody, Biotin conjugated | MyBioSource MBS715566 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit anti-human Gamma-aminobutyric acid receptor-associated protein polyclonal Antibody, Biotin conjugated

catalog :

MBS715566

quantity :

0.05 mg

price :

160 USD

clonality :

polyclonal

host :

rabbit

conjugate :

biotin

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS715566

products type :

Antibody

products full name :

Rabbit anti-human Gamma-aminobutyric acid receptor-associated protein polyclonal Antibody, Biotin conjugated

products short name :

Gamma-aminobutyric acid receptor-associated protein

other names :

gamma-aminobutyric acid receptor-associated protein; Gamma-aminobutyric acid receptor-associated protein; gamma-aminobutyric acid receptor-associated protein; GABA(A) receptor-associated protein; GABA(A) receptor-associated protein; MM46

other gene names :

GABARAP; GABARAP; MM46; ATG8A; GABARAP-a; FLC3B

uniprot entry name :

GBRAP_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

sequence length :

117

purity :

Caprylic Acid Ammonium Sulfate Precipitation

storage stability :

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

tested application :

Western Blot (WB), ELISA (EIA)

other info1 :

Storage Buffer: Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. Conjugate: Biotin

other info2 :

Immunogen: Recombinant human Gamma-aminobutyric acid receptor-associated protein protein

products description :

May play a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton

ncbi gi num :

6005764

ncbi acc num :

NP_009209.1

ncbi gb acc num :

NM_007278.1

uniprot acc num :

O95166

ncbi mol weight :

13,918 Da

ncbi pathways :

Cellular Responses To Stress Pathway (1270414); FoxO Signaling Pathway (921162); GABAergic Synapse Pathway (377263); GABAergic Synapse Pathway (377129); Macroautophagy Pathway (1270432); Regulation Of Autophagy Pathway (83058); Regulation Of Autophagy Pathway (468); Senescence And Autophagy Pathway (198780)

ncbi summary :

Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. This gene encodes GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton. [provided by RefSeq, Jul 2008]

uniprot summary :

GABARAP: is a ubiquitin-like protein that is a constituent of the ATG8-conjugation system, one of two evolutionarily conserved phosphatidylethanolamine conjugation systems necessary for the formation of the autophagosome. The human ATG8 system includes seven ubiquitin-like light chain proteins (LCPs) that are homologs of yeast LC3: MAP1LC3A, -B, -C, GABARAP, GABARAPL1, -2, and -3. Pro-LCPs are cleaved by ATG4B to expose a C-terminal glycine residue, the cytosolic LCP-I form. The exposed C-terminus is conjugated to the head group amine of phosphatidylethanolamine (PE) through an amide bond by a sequence of ubiquitination-like reactions that involves an E1 (ATG7), an E2 (ATG3), and an E3 (a complex including ATG5, ATG12, and ATG16L). The PE-congugated form (LCP-II) is tightly associated with the autophagosomal membrane. The LCP-II forms can also be delipidated by the ATG4 proteases: most of the LCPs are delipidated and liberated from the membrane before autophagosomes fuse with lysosomes. May play a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Belongs to the MAP1 LC3 family. Interacts with GPHN and NSF. Interacts with GABRG2, beta-tubulin and ULK1. Protein type: Vesicle; Adaptor/scaffold; Microtubule-binding; Autophagy; Ubiquitin-like modifier. Chromosomal Location of Human Ortholog: 17p13.1. Cellular Component: actin cytoskeleton; autophagic vacuole; axoneme; cytoplasmic vesicle; cytosol; Golgi membrane; lysosome; microtubule; microtubule associated complex; perinuclear region of cytoplasm; plasma membrane; smooth endoplasmic reticulum. Molecular Function: beta-tubulin binding; GABA receptor binding; microtubule binding; protein binding; ubiquitin protein ligase binding. Biological Process: induction of apoptosis via death domain receptors; macroautophagy; microtubule cytoskeleton organization and biogenesis; protein targeting; synaptic transmission

size1 :

0.05 mg

price1 :

160 USD

size2 :

0.1 mg

price2 :

235

more info or order :

MyBioSource product webpage