Rabbit anti-human 60S ribosomal protein L5 polyclonal Antibody, HRP conjugated | MyBioSource MBS715373 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit anti-human 60S ribosomal protein L5 polyclonal Antibody, HRP conjugated

catalog :

MBS715373

quantity :

0.05 mg

price :

160 USD

clonality :

polyclonal

host :

rabbit

conjugate :

HRP

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS715373

products type :

Antibody

products full name :

Rabbit anti-human 60S ribosomal protein L5 polyclonal Antibody, HRP conjugated

products short name :

60S ribosomal protein L5

other names :

60S ribosomal protein L5; 60S ribosomal protein L5; 60S ribosomal protein L5; ribosomal protein L5

other gene names :

RPL5; RPL5; L5; DBA6; MSTP030; PPP1R135

uniprot entry name :

RL5_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

sequence length :

297

purity :

Caprylic Acid Ammonium Sulfate Precipitation

storage stability :

Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

tested application :

Western Blot (WB), ELISA (EIA)

other info1 :

Storage Buffer: Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. Conjugate: HRP

other info2 :

Immunogen: Recombinant human 60S ribosomal protein L5 protein

products description :

Required for rRNA maturation and formation of the 60S ribosomal subunits. This protein binds 5S RNA.

ncbi gi num :

14591909

ncbi acc num :

NP_000960.2

ncbi gb acc num :

NM_000969.3

uniprot acc num :

P46777

ncbi mol weight :

34,363 Da

ncbi pathways :

Cap-dependent Translation Initiation Pathway (1268680); Cytoplasmic Ribosomal Proteins Pathway (198853); Disease Pathway (1268854); Eukaryotic Translation Elongation Pathway (1268690); Eukaryotic Translation Initiation Pathway (1268679); Eukaryotic Translation Termination Pathway (1268692); Formation Of A Pool Of Free 40S Subunits Pathway (1268681); GTP Hydrolysis And Joining Of The 60S Ribosomal Subunit Pathway (1268686); Gene Expression Pathway (1269649); Infectious Disease Pathway (1269056)

ncbi summary :

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L18P family of ribosomal proteins. It is located in the cytoplasm. The protein binds 5S rRNA to form a stable complex called the 5S ribonucleoprotein particle (RNP), which is necessary for the transport of nonribosome-associated cytoplasmic 5S rRNA to the nucleolus for assembly into ribosomes. The protein interacts specifically with the beta subunit of casein kinase II. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. This gene is co-transcribed with the small nucleolar RNA gene U21, which is located in its fifth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

uniprot summary :

RPL5: Required for rRNA maturation and formation of the 60S ribosomal subunits. This protein binds 5S RNA. Defects in RPL5 are the cause of Diamond-Blackfan anemia type 6 (DBA6). DBA6 is a form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. Belongs to the ribosomal protein L18P family. Protein type: Ribosomal; Translation; Nucleolus. Chromosomal Location of Human Ortholog: 1p22.1. Cellular Component: cytoplasm; cytosol; focal adhesion; membrane; nucleolus; nucleus; ribonucleoprotein complex. Molecular Function: 5S rRNA binding; protein binding; RNA binding; structural constituent of ribosome. Biological Process: cellular protein metabolic process; gene expression; mRNA catabolic process, nonsense-mediated decay; ribosomal large subunit assembly and maintenance; ribosomal large subunit biogenesis and assembly; rRNA processing; selenium metabolic process; selenocysteine metabolic process; SRP-dependent cotranslational protein targeting to membrane; translation; translational elongation; translational initiation; translational termination; viral infectious cycle; viral reproduction; viral transcription. Disease: Diamond-blackfan Anemia 6

size1 :

0.05 mg

price1 :

160 USD

size2 :

0.1 mg

price2 :

235

more info or order :

MyBioSource product webpage