catalog number :
MBS715280
products full name :
Rabbit anti- human UV excision repair protein RAD23 homolog A polyclonal Antibody
products short name :
UV excision repair protein RAD23 homolog A
products name syn :
HR23A hHR23A
other names :
UV excision repair protein RAD23 homolog A isoform 2; UV excision repair protein RAD23 homolog A; UV excision repair protein RAD23 homolog A; RAD23 homolog A, nucleotide excision repair protein
products gene name :
RAD23
other gene names :
RAD23A; RAD23A; HR23A; HHR23A; HR23A; hHR23A
uniprot entry name :
RD23A_HUMAN
purity :
Caprylic Acid Ammonium Sulfate Precipitation Purified
storage stability :
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
tested application :
ELISA (EIA), Wetsern Blot (WB), Immunohistochemistry (IHC)
other info1 :
Storage Buffer: Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4. Conjugate: Non-conjugated
other info2 :
Immunogen: Recombinant human UV excision repair protein RAD23 homolog A protein
products description :
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiqui
ncbi acc num :
NP_001257291.1
ncbi gb acc num :
NM_001270362.1
ncbi mol weight :
39,538 Da
ncbi pathways :
DNA Damage Recognition In GG-NER Pathway (1309113); DNA Repair Pathway (1270350); Formation Of Incision Complex In GG-NER Pathway (1309114); Global Genome Nucleotide Excision Repair (GG-NER) Pathway (1309112); Nucleotide Excision Repair Pathway (1309111); Nucleotide Excision Repair Pathway (83044); Nucleotide Excision Repair Pathway (452); Protein Processing In Endoplasmic Reticulum Pathway (167325); Protein Processing In Endoplasmic Reticulum Pathway (167190)
ncbi summary :
The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair. Proteins in this family have a modular domain structure consisting of an ubiquitin-like domain (UbL), ubiquitin-associated domain 1 (UbA1), XPC-binding domain and UbA2. The protein encoded by this gene plays an important role in nucleotide excision repair and also in delivery of polyubiquitinated proteins to the proteasome. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Jun 2012]
uniprot summary :
RAD23A: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. Belongs to the RAD23 family. Protein type: DNA repair, damage; DNA-binding. Chromosomal Location of Human Ortholog: 19p13.2. Cellular Component: nucleus; proteasome complex. Molecular Function: damaged DNA binding; polyubiquitin binding; protein binding; single-stranded DNA binding. Biological Process: nucleotide-excision repair; positive regulation of viral genome replication; proteasomal ubiquitin-dependent protein catabolic process; regulation of proteasomal ubiquitin-dependent protein catabolic process; viral reproduction